Do you want to help us improve human health and understand life on Earth? Make your mark by shaping the future to enable or deliver life-changing science to solve some of humanity’s greatest challenges. We are seeking a highly motivated and creative Postdoctoral Fellow or Senior Postdoctoral Fellow to join the Martin group at the Wellcome Sanger Institute, to develop and apply statistical and machine learning methods to cell-free DNA from pregnant women and people. About the group: The Martin group works on the genetic basis of rare and common disease, using large-scale human genetic datasets with rich linkage to electronic health records and questionnaires. Over the last few years, we have had a particular emphasis on the genetics of neurodevelopmental disorders and related traits, the genetics of complex disease in populations with high levels of consanguinity, and factors influencing germline mutation rates. The group is now opening new research directions involving genomics and multi-omics in very early life. Most conditions in the earliest stages of life remain untouched by large-scale genomics, and molecular predictors that could guide clinical management are urgently needed. We are building a programme spanning a clinical continuum from pregnancy loss, through fetal growth restriction, to complications of premature birth. This includes large-scale sequencing of cell-free DNA (cfDNA) from pregnant women and people to identify monogenic causes of pregnancy loss and identify biomarkers for fetal growth restriction, as well as genetic and multi-omic studies of neonatal conditions using nationwide dried blood spots. What you'll be doing: This particular role is focused on cell-free DNA (cfDNA) from pregnant women and people. cfDNA in maternal plasma is a mixture of maternal and fetal (placental) molecules, and offers a route to studying fetal genomes and placental biology at a scale that is impossible with fetal tissue. Possible projects include: Developing new statistical and deep learning methods for calling fetal and maternal genotypes from high-coverage sequence data on cfDNA, and for discovering new Mendelian disease genes using the resulting data. These methods will then be applied to study pregnancy complications in large samples. Developing biomarkers for pregnancy complications from methylation-aware wholegenome sequence data on cfDNA, including methods development to incorporate both epigenetic and genetic information in the same assay. You will have the opportunity to collaborate with groups at the Norwegian Institute of Public Health (Siri Eldevik Håberg), the University of Helsinki (Simone Rubinacci) and elsewhere. About you: We are recruiting at two levels: Postdoctoral Fellow and Senior Postdoctoral Fellow. In both cases, you will have a demonstrable background in statistics or statistical genetics. Experience of working with cfDNA is highly desirable but not essential. The role would particularly suit if you have previously worked on methods for somatic variant calling, or for phasing and imputation from low-coverage sequence data.You would also bring excellent software development skills, since the methods developed here are intended to be applied across several large cohorts and shared with collaborators. The Senior Postdoctoral Fellow role is intended for someone with particularly strong experience in these areas who is ready to work with a high degree of independence, to shape the direction of the methods development, to lead collaborations and to mentor more junior members of the group. You will be considered at the level that best matches your experience, so please apply even if you are unsure which position fits. Prospective candidates are welcome to contact Hilary Martin (hcm@sanger.ac.uk) with informal queries before deciding whether to apply. Essential Skills: PhD in a relevant area (statistics, statistical genetics, genetics, genomics, bioinformatics, machine learning or similar) Strong background in statistics or statistical genetics, including the ability to develop, implement and benchmark new statistical methods Experience working with raw sequence data (alignments, variant calling, quality control) Experience analysing large-scale human genetic or genomic data Full working proficiency in Python and/or R, and Unix/Linux Experience or enthusiasm for using AI tools to improving productivity in scientific research, statistical methods development and/or software development Knowledge and understanding of statistical methods appropriate for large-scale genetic research Previous experience writing highly reproducible code with github, Snakemake/Nextflow, RMarkdown or similar Experience developing pipelines or software for large-scale analyses of genomic data, including running workflows efficiently on HPC and/or cloud infrastructure Creativity and original scientific ideas Enthusiasm and commitment Attention to detail Effective problem-solving skills Ability to communicate ideas and results effectively both verbally and in writing Ability to prioritise, work independently and organise own workload Ability to collaborate effectively with an interdisciplinary team and collaborators Senior Postdoctoral Fellow as above, with the following additional skills: Completion of a previous postdoctoral position, or other highly relevant training or experience Experience of developing methods for variant calling from sequence data, or for phasing and imputation from low-coverage sequence data Evidence of substantial research contributions and intellectual leadership, demonstrated through publications, methods, software or other relevant outputs, appropriate to career stage and opportunities. Specialist knowledge and understanding to drive the project from the outset Demonstrated ability to lead collaborations and to supervise or mentor junior researchers You will join our supportive and collaborative Postdoctoral Fellow community, with access to training, learning and networking across the Institute. Other information: For further details, please see role profile for Postdoctoral Fellow and Senior Postdoctoral Fellow. Contract length: 3 years Salary per annum (dependent upon skills and experience): £38,570-£49,893 For Senior Postdoctoral Fellow (dependent upon skills and experience): £44,305-£49,893 Application Process: Please apply with your CV and a Cover letter outlining how you meet the skills set out above for the Postdoctoral Fellow or Senior Postdoctoral Fellow position. Closing Date: 10th November 2026 Hybrid Working at Wellcome Sanger: We recognise that there are many benefits to Hybrid Working; including an improved work-life balance, with more focused time, as well as the ability to organise working time so that collaborative opportunities and team discussions are facilitated on campus. The hybrid working arrangement will vary for different roles and teams. The nature of your role and the type of work you do will determine if a hybrid working arrangement is possible. Equality, Diversity and Inclusion: We aim to attract, recruit, retain and develop talent from the widest possible talent pool, thereby gaining insight and access to different markets to generate a greater impact on the world. We have a supportive culture with the following staff networks: LGBTQ+, Parents and Carers, Disability, Gender Equity and Race Equity to bring people together to share experiences, offer specific support and development opportunities and raise awareness. The networks are also a place for allies to provide support to others. We believe people do their best work when they can be their authentic selves. That’s why we’re committed to creating a truly inclusive culture at Sanger Institute. We will consider all individuals without discrimination and are committed to creating an inclusive environment for all employees, where everyone can thrive. Our Benefits: We are proud to deliver an awarding campus-wide employee wellbeing strategy and programme. The importance of good health and adopting a healthier lifestyle and the commitment to reduce work-related stress is strongly acknowledged and recognised at Sanger Institute. Sanger Institute became a signatory of the International Technician Commitment initiative In March 2018. The Technician Commitment aims to empower and ensure visibility, recognition, career development and sustainability for technicians working in higher education and research, across all disciplines. Life at the Sanger Institute is unique. We are tackling some of the most difficult challenges in genomic research. Our people are shaping the future by delivering life-changing science with the reach, scale, and creativity to solve some of humanity’s greatest challenges. We aim to attract, recruit, retain and develop talent from the widest possible talent pool, thereby gaining insight and access to different markets to generate a greater impact on the world. We offer an attractive benefits package at the Wellcome Sanger Institute. We appreciate the importance of achieving work-life balance and support this with a number of family and carer-friendly policies. Plus a flexible working policy for those who may wish to amend their working pattern or arrangement. Each year, the Wellcome Sanger Institute welcomes researchers from around the world to the Genome Campus to collaborate and drive cutting-edge science. Whether you're joining as faculty, a postdoc, or a visitor, our dedicated International Team offers expert guidance and support throughout your journey, promoting the Institute’s global and collaborative ethos.

cfDNA Postdoctoral Fellow / Senior Postdoctoral Fellow in statistical genomics.

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