Staff Engineer, Software (Deployment) PacBio (NASDAQ: PACB) is a premier life science technology company that designs, develops, and manufactures advanced sequencing solutions to help scientists and clinical researchers resolve genetically complex problems. Our mission is to enable the promise of genomics to better human health. Genomics is core to all biological processes, and our advanced genomics tools provide scientists and clinical researchers the insights to better understand biology and health. We are now entering the century of biology and genomics is at the heart of the next revolution. Become part of the new paradigm in gene sequencing and help shape the future of genomic study by joining the PacBio team. Position Summary: PacBio’s sequencing instruments are critical to sequencing labs around the world. As a Staff Deployment Engineer, you will work cross-functionally to design, develop, and deploy the compute platforms integrated into our sequencing appliances, our customers’ data centers, and the cloud. You will be expected to set technical direction rather than receive it: to decide what our deployment and platform architectures should look like several years out, build the pieces that do not exist yet, and deliver a product that satisfies CLIA labs and other regulated customers. Responsibilities: Cloud deployment. Bring core data analysis pipelines to the cloud to offer flexible, on-demand compute capacity for our customers. Provide a secure, reliable, and transparent alternative to on-prem compute. Define and implement the deployment model for cloud-hosted services, including infrastructure as code, environment promotion, secrets management, and delivery pipelines, and establish the patterns other teams will adopt. Build and release pipelines. Consolidate build infrastructure onto a single CI/CD platform, moving builds into containers so they are reproducible and independent of hand-maintained agents. Rationalize dependency management, proselytize statelessness and immutability, and instrument deployment pipelines for predictability and uptime. Develop and implement traceability and retention policies for product lifecycle management. Image architecture and hardware integration. Own image architecture jointly with instrument engineering: composition, maintainability, and performance across node roles and hardware variants. You will build the images themselves with curated package sets, PacBio software, purposeful partition layouts, and the driver, device, and firmware integration each variant requires. This includes virtual machines in production and virtualized server equivalents used for development and test. Support custom hardware interfaces, robotics packages, and low-latency user interfaces. Infrastructure and Configuration as code. Replace bespoke scripting and image-baked state with declarative, reviewable configuration for instruments, build infrastructure, and laboratory systems. Supply-chain integrity and security posture. Establish the assurance capability the product needs: artifact and image signing, verified boot, automated software bill of materials generation, continuous vulnerability ingestion and triage against a defined patch cadence, and a documented hardening baseline. Cross-functional and regulatory execution. Partner with Quality, Regulatory, Manufacturing, IT, and Field Service to make deployment auditable and predictable: traceability from commit to shipped artifact, change control and release documentation, and validated builds delivered to manufacturing on schedule. Technical leadership and resilience. Set engineering standards, review designs and code, and mentor engineers across the organization. Document and de-risk the systems that currently rely on individual knowledge. Required Qualifications: 10+ years of professional experience in systems, platform, release, or deployment engineering, or a Master’s degree in computer science, computer engineering, or a related discipline plus 8+ years of such experience. Demonstrated experience delivering Linux-based systems on appliance, instrument, or other purpose-built hardware into customer or field environments. Fluency in Python and shell, sufficient to build and maintain production automation that others depend on. Deep, hands-on Linux systems expertise: boot chain, systemd, filesystems and partitioning, packaging, and kernel or driver integration. Experience designing and operating automated, reproducible image build pipelines, with a clear point of view on what makes a build trustworthy. Experience delivering software under formal change control in a regulated or otherwise high-consequence setting, where releases must be auditable and any prior version reproducible on demand. Strong hands-on ownership of CI/CD systems at scale, including pipeline-as-code, containerized builds, build agent fleet management, and infrastructure as code. Production experience deploying cloud services for customer use with at least one major cloud platform (AWS, Azure, or GCP). A track record of setting technical direction for a platform and driving it to completion across multiple teams, including the parts that require persuasion rather than authority. Excellent interpersonal, written, and verbal communication skills. Preferred Experience: Supply-chain security experience: code and artifact signing, UEFI Secure Boot, dm-verity or equivalent integrity measures, SBOM generation, and software composition analysis tooling. Familiarity with hardening baselines and audit tooling such as CIS Benchmarks, STIG, SCAP, or SELinux policy work. Experience with modern image build tooling such as mkosi, Packer, Yocto, or Buildroot, and with immutable or A/B-updated operating systems. Configuration management and infrastructure-as-code experience with tools such as Ansible, Terraform, or Salt. Experience owning on-premises development infrastructure systems such as Bitbucket, Jenkins, and Artifactory as an end-to-end administrator and architect, not only as a consumer. Experience building or operating an observability stack (for example Prometheus, Grafana, Loki, and Alertmanager). Experience managing secure remote access management systems (for example Tailscale or SecureLink). Experience with on-premises virtualization at scale, such as Proxmox VE or VMware vSphere. Experience mentoring senior engineers or acting as a technical lead without direct reports. Candidates must have current authorization to work in the United States without the need for present or future sponsorship. You may be required from time to time to visit and work at PacBio locations and for such times as the Company considers necessary for the proper performance of your duties. All listed tasks and responsibilities are deemed as essential functions to this position; however, business conditions may require reasonable accommodations for additional tasks and responsibilities. All qualified applicants will receive consideration for employment without regard to race, sex, color, religion, national origin, protected veteran status, or on the basis of disability, gender identity, and sexual orientation. #LI-Onsite Salary Range: $170,400.00 - $255,600.00 To all Staffing and Recruiting Agencies: Our Careers Site is only for individuals seeking a job at PacBio. Staffing and recruiting agencies and individuals being represented by an agency are not authorized to use this site or to submit profiles, applications or resumes, and any such submissions will be considered unsolicited. PacBio does not accept unsolicited resumes or applications from agencies. Please do not forward resumes to our jobs alias, PacBio employees or any other company location. PacBio is not responsible for any fees related to unsolicited resumes/applications. All qualified applicants will receive consideration for employment without regard to race, sex, color, religion, national origin, protected veteran status, or on the basis of disability, gender identity, and sexual orientation. If you are an individual with a disability and require a reasonable accommodation to complete any part of the application process, or are limited in the ability or unable to access or use this online application process and need an alternative method for applying, you may contact us at 650-521-8000, or careers@pacificbiosciences.com for assistance. Visit our following pages for more information on: FAQs Benefits Culture Equal Opportunity Employment At PacBio, we’re all on a mission to enable the promise of genomics to better human health. It’s what fuels us every day. Our team is passionate about catalyzing scientists pursuing biological discoveries, and we’re looking for exceptional individuals like you to join us. If you’re interested at being at the intersection where health and technology come together, then consider joining our team. We look forward to meeting you. CORE VALUES: BE CURIOUS. Our future depends on it. DELIGHT OUR CUSTOMERS. We strive to get it right every time. TAKE ACTION. We move fast and take calculated risks. EXECUTION MATTERS. Our customers rely on us. WORK TOGETHER. We care deeply about each other. Please be aware of employment scams where people or entities misuse PacBio’s name, or the names of PacBio employees, to post fake job advertisements or make fake job offers. PacBio will never extend a job offer without a personal interview and will never charge any money for joining our company. All current job openings are displayed on the Careers page of our official website. If you see a job posting that is not on the PacBio official website, or have been approached with a job offer that you suspect may be fraudulent, we strongly recommend you do not respond and do not send money or provide any personal information. IT IS LIKELY A SCAM OR FAKE JOB AD IF: The job offer requires you to pay something (for example, to purchase equipment). You receive a job offer that you didn’t apply for, or without a personal interview or interaction. The interview seems to involve AI video or audio. You found a job on a job board or third-party channel, but the job doesn’t exist on the official PacBio careers page You suspect it is a scam. HOW TO PROTECT YOURSELF: Never give personal and confidential information. Never pay for anything as part of interviewing for, or accepting, an offer of employment. Ignore it if it seems like a scam.

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