Job Description General Summary: The Commercial Distributor & Expansion Markets Director will manage and oversee Vertex’s business with third party partners in the Expansion Markets and Assigned region to ensure that all eligible patients gain access to Vertex's medicines in the territory. The incumbent will work closely with Vertex’s distributor partners in the region, ensures alignment with international commercial strategy, implements tactical plans and ensures compliance with Vertex’s policies, procedures, and expectations. Key Duties and Responsibilities: Leads the development, management and execution of the Assigned Region / Expansion Markets regional strategic plans in collaboration with Vertex’s distributor partners Ensures brand strategy is aligned with the Commercial International strategic objectives Enforces a culture of compliance and best practice as well as a commitment to continuously improves efficiency and effectiveness of region operations Oversees planning, analytics and project implementation to ensure successful delivery Ensures short and long term revenue opportunities are maximized in order to achieve commercial targets Interacts with local payers, KOLs, patient organizations, and key stakeholders Oversees and develops necessary KPIs; monitor, report and suggest action when needed Works cross-functionally within Vertex and locally with the distributor team as necessary to ensure smooth operation of region Partners and collaborates with compliance and legal teams to ensure operations are compliant with country laws and regulations Manages LE forecasts and expenses on a monthly basis with the required accuracy Supports expansion in the region including leading the cross functional CET (Country Expansion Team) for new market build out Conducts all project management activities for markets in build phase to execute on market entry strategy including development of project plans and timelines, country level expansion teams, monthly meetings to ensure tracking of milestones and functional activity dependency triggers Works with GM to ensure effective internal evaluation of each market including definition of cross-functional impact assessments, market entry strategy and requirements, resources and business case development Ensures effective communication and alignment across the functional matrix regarding the strategy, plan and progress of implementation Leads consulting agencies to conduct detailed analyses in market of interest and deliver high quality, actionable strategic plans Knowledge and Skills: Experience in Commercial operations, preferably in the assigned region Strong and successful background in sales and marketing Experience in managing third party commercial relationships and budgets Strong team player with excellent interpersonal, communication, and presentation skills to communicate complex concepts and negotiate with others mainly internally Ability to work cross-functionally as well as autonomously Ability to interact with payors, regulators and various stakeholders Solid understanding of the compliance framework Adept at working in multiple countries/cultures Ability to develop rapport and credibility with key internal and external stakeholders Proven ability to manage complex projects within timeline and budget Ability to plan, adjust, manage and optimize resources Proficiency in developing and overseeing country plans Entrepreneurial with a strong business acumen Ability to travel up to 50% Fluent Spanish; strong English; ideally Portuguese or ability to operate in Brazil; willingness to relocate to São Paulo Education and Experience: Bachelor’s degree in relevant discipline Typically requires 10 years of experience with some experience in commercial pharmaceuticals, or the equivalent combination of education and experience At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time. #LI-Hybrid Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com Help Us Achieve Our Mission Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases and conditions. The company has approved therapies for cystic fibrosis, sickle cell disease, transfusion-dependent beta thalassemia, acute pain and acromegaly, and it continues to advance clinical and research programs in these areas. Vertex also has a robust clinical pipeline of investigational therapies across a range of modalities in other serious diseases where it has deep insight into causal human biology, including IgA nephropathy, neuropathic pain, APOL1-mediated kidney disease, primary membranous nephropathy, congenital adrenal hyperplasia, ACTH-dependent Cushing's syndrome, autosomal dominant polycystic kidney disease, type 1 diabetes, generalized myasthenia gravis, and myotonic dystrophy type 1. Vertex was founded in 1989 and has its global headquarters in Boston, with international headquarters in London. Additionally, the company has research and development sites and commercial offices in North America, Europe, Australia, Latin America and the Middle East. Vertex is consistently recognized as one of the industry's top places to work, including 16 consecutive years on Science magazine's Top Employers list and one of Fortune’s 100 Best Companies to Work For. For company updates and to learn more about Vertex's history of innovation, visit www.vrtx.com or follow us on LinkedIn, Facebook, Instagram, YouTube, and X We believe our culture is one of Vertex’s greatest strengths and a key enabler of our ability to deliver transformative medicines for patients who need them. Rooted in innovation, purpose and collaboration, our culture empowers people to take smart risks, challenge conventional thinking and do their best work. The diversity of our people is central to that culture. By bringing together individuals with different backgrounds, experiences and perspectives, we foster an environment where new ideas thrive, better decisions are made and breakthrough innovation is possible. We are committed to creating a workplace where everyone feels valued, included and connected to our shared mission, because we know that our unique culture and the collective strength of our people are what set Vertex apart.

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