Job Description Financial Planning & Analysis Senior Manager General/Position Summary The Senior Manager, G&A Functions, is a key member of Vertex's Financial Planning & Analysis team, providing financial direction and strategic insight including identification of key value drivers and business KPIs, helping functions deliver their short-term and long-term goals and influencing strategy. This role will help drive our annual budget process and will partner closely with functional teams to drive the financial performance management process for responsible functions (objective setting, budget vs. actuals, etc.), including the monthly forecast process, with a focus on influencing business operations and decisions through an understanding of the key drivers of short-term performance and communicating the range of possible outcomes. Key Duties & Responsibilities Business Partnering & Stakeholder Management • Serve as the strategic finance partner to leaders across assigned G&A functions, building trusted relationships and providing financial counsel, decision support, and constructive challenge to help achieve short- and long-term objectives. Financial Planning, Analysis & Performance Management • Lead the annual budget, forecast, and long-range planning processes for assigned functions, translating business strategies and operating plans into clear financial requirements, scenarios, and resource-allocation recommendations. • Drive financial performance management through monthly and quarterly reviews of actual results, forecasts, and key performance indicators; identify underlying drivers, explain variances, and maintain transparent views of risks and opportunities. • Partner with Human Resources and functional leaders on workforce planning, headcount forecasting, vacancy management, and organizational changes, ensuring associated financial impacts are accurately reflected in plans and forecasts. Reporting, Close & Financial Controls • Establish and maintain clear, scalable reporting and analytics that provide leaders with timely insight into spending trends, business drivers, forecast accuracy, and progress against functional objectives. • Partner with Accounting and functional stakeholders to support monthly and quarterly close activities for assigned functions, including accruals, purchase-order and commitment reviews, variance analysis, and compliance with applicable internal controls. Communication & Cross-Functional Collaboration • Prepare and present concise financial updates that synthesize complex information, highlight key decisions and trade-offs, and recommend actions to address emerging risks and opportunities. • Collaborate across the CFO organization, including Corporate Finance, Accounting and other finance teams, to align assumptions, strengthen controls, share best practices, and deliver efficient end-to-end processes. Innovation & Continuous Improvement • Identify and support continuous-improvement opportunities by simplifying processes and appropriately leveraging automation, AI, analytics, and visualization tools to improve forecast accuracy, reporting efficiency, and decision support. Required Education Level Bachelors Degree in Finance or Accounting Required Experience · Typically requires 8 years of progressive experience in finance roles (FP&A, business partnering, or related areas) demonstrating strong technical and analytical skills and a proven track record of success working in a team-based environment or the equivalent combination of education and experience. · Biotechnology/Pharmaceutical industry experience preferred Required Knowledge/Skills Core Financial & Analytical Expertise Advanced financial planning and analysis expertise, including budgeting, forecasting, long-range planning, management reporting, scenario analysis, and financial modeling. Exceptional analytical and problem-solving skills, with the ability to synthesize large and complex data sets, identify key value drivers, challenge assumptions, develop pragmatic recommendations under uncertainty, and drive ideas through successful implementation. Strong understanding of accounting and finance principles, including accruals, operating expense management, variance analysis, financial controls, and the monthly and quarterly close process. Business Partnering & Communication Demonstrated ability to serve as a trusted advisor to senior leaders, understand functional strategies and operating models, and translate business priorities into actionable financial insights and resource-allocation recommendations. Excellent written and verbal communication skills with the ability to explain complex financial concepts clearly to finance and non-finance audiences. Strong stakeholder-management and influencing skills, with a demonstrated ability to build trusted relationships, work effectively with senior leaders, peers, and junior team members, align diverse perspectives, and influence decisions across functions and organizational levels. Technology, Innovation & Continuous Improvement Advanced proficiency in Excel and PowerPoint; experience with Hyperion, Oracle EPM, SAP BPC, or a comparable planning platform. Experience with business-intelligence and visualization tools such as Tableau or Power BI is preferred. Continuous improvement mindset with demonstrated interest in process simplification, automation, AI-enabled analytics, data quality, and emerging finance technologies; experience with lean tools or lean philosophies is preferred. Other Requirements This position is based in our Boston, MA location and requires a hybrid work schedule with 3 days in office / 2 days remote on a weekly basis. #HYBRID #LI-MF1 At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients. Pay Range: $134,400 - $201,600 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time. #LI-Hybrid Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com Help Us Achieve Our Mission Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases and conditions. The company has approved therapies for cystic fibrosis, sickle cell disease, transfusion-dependent beta thalassemia, acute pain and acromegaly, and it continues to advance clinical and research programs in these areas. Vertex also has a robust clinical pipeline of investigational therapies across a range of modalities in other serious diseases where it has deep insight into causal human biology, including IgA nephropathy, neuropathic pain, APOL1-mediated kidney disease, primary membranous nephropathy, congenital adrenal hyperplasia, ACTH-dependent Cushing's syndrome, autosomal dominant polycystic kidney disease, type 1 diabetes, generalized myasthenia gravis, and myotonic dystrophy type 1. Vertex was founded in 1989 and has its global headquarters in Boston, with international headquarters in London. Additionally, the company has research and development sites and commercial offices in North America, Europe, Australia, Latin America and the Middle East. Vertex is consistently recognized as one of the industry's top places to work, including 16 consecutive years on Science magazine's Top Employers list and one of Fortune’s 100 Best Companies to Work For. For company updates and to learn more about Vertex's history of innovation, visit www.vrtx.com or follow us on LinkedIn, Facebook, Instagram, YouTube, and X We believe our culture is one of Vertex’s greatest strengths and a key enabler of our ability to deliver transformative medicines for patients who need them. Rooted in innovation, purpose and collaboration, our culture empowers people to take smart risks, challenge conventional thinking and do their best work. The diversity of our people is central to that culture. By bringing together individuals with different backgrounds, experiences and perspectives, we foster an environment where new ideas thrive, better decisions are made and breakthrough innovation is possible. We are committed to creating a workplace where everyone feels valued, included and connected to our shared mission, because we know that our unique culture and the collective strength of our people are what set Vertex apart.

Senior Manager, G&A Functions.

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