Postdoctoral Associate | Cardiac Physiology and Functional Genomics Hinson Lab Farmington, CT The Hinson lab at The Jackson Laboratory for Genomic Medicine and UConn Health is seeking an independent, highly motivated PhD-level scientist to join our group studying the mechanisms of inherited heart failure and other muscle disorders. We combine human pluripotent stem cell biology, tissue engineering, genome editing, and multi-omics assays to understand how genetic variants disrupt heart function, and to develop therapies that correct it. Depending on the candidate’s interests and expertise, projects may include: Cardiac physiology in 3D engineered heart tissue (EHT) models. Use human iPSC-derived EHTs and microtissues to measure contractile force, kinetics, and calcium handling, with the goals of modeling disease and testing therapeutic strategies. Mouse models of heart failure. Characterize cardiac structure and function in vivo, including echocardiography and molecular and histological phenotyping, and use these models to validate mechanisms and therapies. Large-scale in vivo genetic perturbation. Apply pooled, Perturb-seq-style approaches in the heart to define gene function and disease mechanisms at scale, paired with single-cell and multi-omic readouts. Sarcomere assembly and function. Collaborate with an international network of scientists in pluripotent stem cell biology, 3D microtissue assays, super-resolution microscopy, and structural biology to define the mechanisms and rules of sarcomere assembly. Qualifications PhD (or equivalent) in cell biology, molecular biology, physiology, genetics, bioengineering, or a related field. Strong background in at least one of: stem cell differentiation, cardiac or muscle physiology, mouse models of disease, genome editing (CRISPR), or single-cell genomics. Experience with advanced imaging, protein-protein interaction studies, or computational analysis of sequencing data is a plus. A record of scientific productivity, including publications, and strong written and verbal communication skills. Ability to work independently and collaboratively in a multidisciplinary team. **Please submit your current CV, at least 2 letters of reference, and 1-page (maximum) statement of Research Interests and Career Goals at time of application. We are a diverse and inclusive research group, aspiring to produce top science and scientists through attentive and progressive mentoring and interdisciplinary teamwork. JAX Salary Year 0 - 1: $65,589 Year 1 - 2: $67,318 Year 2 - 3: $69,095 Year 3 - 4: $70,521 Year 4 - 5: $72,877 Year 5 - 6: $75,569 Based on years of experience as Postdoc About JAX: The Jackson Laboratory is an independent, nonprofit biomedical research institution with a National Cancer Institute-designated Cancer Center and nearly 3,000 employees in locations across the United States (Maine, Connecticut, California, New York, Florida), Japan and China. Its mission is to discover precise genomic solutions for disease and empower the global biomedical community in the shared quest to improve human health. Founded in 1929, JAX applies over nine decades of expertise in genetics to increase understanding of human disease, advancing treatments and cures for cancer, neurological and immune disorders, diabetes, aging and heart disease. It models and interprets genomic complexity, integrates basic research with clinical application, educates current and future scientists, and provides critical data, tools and services to the global biomedical community. For more information, please visit www.jax.org. EEO Statement: The Jackson Laboratory provides equal employment opportunities to all employees and applicants for employment in all job classifications without regard to race, color, religion, age, mental disability, physical disability, medical condition, gender, sexual orientation, genetic information, ancestry, marital status, national origin, veteran status, and other classifications protected by applicable state and local non-discrimination laws. Bar Harbor: The Jackson Laboratory's 43-acre scenic Bar Harbor campus is nestled between the Gulf of Maine and the mountains of Acadia National Park. Some of the best hiking and biking in the world (over 50 square miles of mountains, lakes, views, and dramatic coastline) is accessible from our campus. We are one mile from downtown Bar Harbor, which offers a vibrant downtown district with a plethora of restaurants, shops, museums, and galleries. Ellsworth: The Charles E. Hewett Center in Ellsworth, Maine, is a state-of-the-art facility that serves researchers world wide. The facility represents the culmination of nine decades of unmatched experience and leadership in breeding and caring for laboratory mice. Ellsworth, Maine, is one of Maine’s fastest growing cities. With a growth rate of nearly 20%, Ellsworth is a bustling year-round community and acts as a hub for surrounding towns. It is located nearby Acadia National Park and hosts numerous special events, concerts and festivals each year. Residents have access to fabulous shopping, recreation, museums, galleries, and dining at a variety of independent restaurants. Farmington: JAX Genomic Medicine is transforming medicine by improving patient care, lowering costs, and increasing life span and health span. JAX Genomic Medicine’s research focuses on the complex genetic causes of disease and on the development of genomic solutions tailored to each person's unique genetic makeup. JAX Genomic Medicine sits on a 17-acre site on the campus of the University of Connecticut Health Center. The 183,500-square-foot facility opened in the fall of 2014. Now, it houses over 300 biomedical researchers, technicians, and support staff in state-of-the-art computing facilities and laboratories. In Connecticut, JAX resides in the scenic town of Farmington, in the state’s capitol region. The Hartford region, which offers some of the best public schools in the country, is made up of both bigger cities and smaller, charming historic New England towns. JAX Genomic Medicine is also geographically located within 2 hours of Boston and New York and is close to multiple transportation systems, including bus lines, highways, railroads and international airports. Sacramento: The JAX® Mice, Clinical and Research Services facility is located in Sacramento, the state capital of California. Sacramento is less than a two-hour drive from San Francisco, Napa Valley, and scenic Lake Tahoe, and a short flight to both Los Angeles and Orange County. Sacramento is the birthplace of the nation’s Farm to Fork movement, and offers excellent restaurants, gastro-pubs, wineries, theaters, and museums. Outdoor activities are plentiful: Boating, white water rafting, and riding the scenic bicycle trails are popular. Housing and other costs of living are more affordable in Sacramento and its surrounding suburbs than in most other neighboring areas in the North Bay, making Sacramento one of the hottest housing markets in the country year after year. Augusta: JAX’s Maine Cancer Genomics Initiative (MCGI) is located in Augusta, Maine, in the Harold Alfond Center for Cancer Care (HACCC), at Maine General Hospital. It began operations in 2016 with three overarching goals: to provide cancer genomic testing for Maine cancer patients; to develop and deliver physician education about clinical genomic cancer diagnostics; and to build a network in Maine of oncology practices conducting studies in genomic medicine.

Postdoctoral Associate | Cardiac Physiology and Functional Genomics | Hinson Lab.

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