Summary: The Senior Clinical Program Director is accountable for the overall delivery of the clinical program to time, cost and quality and is the leader of the Clinical Program Team (CPT). You will be required to work closely with the core CPT members to ensure that the clinical strategy and deliverables for the clinical program are delivered to the Global Project Team (GPT). The role provides strategic oversight and feasibility input into the design of the clinical program and plays a key role in the work required to determine possible program design options. The focus is across the program level, collaborating with CPT members, GPT colleagues and all other functions that are key to the development of a compound. The SrCPD is expected to be a highly experienced drug developer and have organizational understanding and influence. You will drive and guide the CPT and each of its functions and enhance teamwork, productivity and depth of quality. This person will be responsible for driving the clinical strategy, implementation and forward planning. The SrCPD, as the CPT Leader, will drive/guide the GPT in aspects related to the clinical development plan and influence from pre-Clinical to Commercial with other core CPT members. The role will establish and monitor best practices and be responsible for quality goal setting for the CPT deliverables. Location: Cambridge, MA or Gaithersburg, MD Accountabilities: Accountable for leading the CPT and its oversight of clinical program strategy activities and deliveries within assigned programs and for ensuring the implementation of innovative approaches to delivery of the clinical program Accountable for leading the translation of science into crisp clinical development plans Accountable for providing efficient and effective program management of all CPT deliverables, including project strategy, design and delivery of CPT driven program/studies to time, on budget and with quality Accountable for providing strategic and operational input to cross-functional program development plans and be accountable for cross-functional leadership roles as delegated from the GPT Accountable for ensuring governance preparation and ensuring operational review. Accountable for coordinating and actively presenting the clinical components at the reviews Accountable for ensuring initial feasibility assessment and early country and site engagement to optimize clinical program delivery Accountable for developing and managing contingency risk plans within each assigned clinical program, including management of program issue escalation and resolution Accountable for accurate budget forecasting, and maintenance, and monitoring to baseline, clinical program resourcing, scenario planning, plus overall timelines for trials within assigned program, including setup and maintenance within Company systems Ensure consistent quality practices in alignment with highest ethical standards, GCP, ICH Guidelines, compliance with internal SOPs, local regulations and laws, etc Contribute to driving best practices and support process-related improvements and workstreams, and ensuring timely compliance with Company governance controls Provide mentorship and support people development as required Experience and Education: Master/PhD of Science degree in natural sciences or medicine (advanced degree is preferred) At least 10 years of global pharmaceutical drug development and leadership experience demonstrated in a variety of roles and at least 5 years clinical development experience Proven ability to apply strategic thinking and develop clinical programs to meet business goals and to assess business risk versus potential value Proven ability to lead teams in dynamic environments with a high demand on pro-active scenario planning Verified ability in problem solving and issues management that are solution focused Proven experience of leading delivery through collaboration within globally matrixed teams, including internal organization and external providers and drive delivery to timelines, cost and quality Significant experience of program management and use of project management techniques in complex projects, including resourcing, financial management and business case development Strong strategic influencing skills; ability to influence broadly within and outside the organization Excellent communication skills; proven teamwork and ability to work collaboratively across a wide range of disciplines and a track record of planning and delivery success Desirable: Program management qualification/certification. Experience in variety of organizations and countries At least 10 years clinical development experience Experience across the product life cycle and ideally across multiple therapeutic areas When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world. The annual base pay (or hourly rate of compensation) for this position ranges from $233,586 to $350,379. Our positions offer eligibility for various incentives an opportunity to receive short-term incentive bonuses, equity-based awards for salaried roles and commissions for sales roles. Benefits offered include qualified retirement programs, paid time off (i.e., vacation, holiday, and leaves), as well as health, dental, and vision coverage in accordance with the terms of the applicable plans. Why AstraZeneca: Here you will contribute to a bold mission to transform outcomes for people by advancing earlier detection and smarter, faster trials. You will operate at the intersection of innovative science and technology, backed by significant investment and an empowered, collaborative culture that brings clinicians, scientists, and data experts together to accelerate breakthroughs. We value kindness alongside ambition, giving you the trust, tools, and cross-functional partnerships to lead with confidence and shape studies that matter—so your decisions today translate into meaningful patient impact tomorrow. Call to Action: Step into this country leadership role to accelerate life-changing trials and turn bold science into result that matter—make your move and help shape what comes next. Date Posted 05-Oct-2026 Closing Date Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form. AstraZeneca is a global, science-led, patient-focused biopharmaceutical company. We focus on discovering, developing and commercialising prescription medicines for some of the world’s most serious diseases. But we are more than one of the world’s leading pharmaceutical companies. At AstraZeneca, we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science, challenge convention and unleash your entrepreneurial spirit. To embrace differences and take bold actions to drive the change needed to meet global healthcare and sustainability challenges. There is no better place to make a difference in medicine, patients, and society. An inclusive culture where you will connect different thinking to generate new and valuable opportunities. Where you will find a commitment to lifelong learning, growth and development for all. Our Inclusion & Diversity (I&D) mission is to create an inclusive and equitable environment where people belong, using the power of our diversity to push the boundaries of science to deliver life-changing medicines to patients. Inclusion and diversity are fundamental to the success of our company, because innovation requires breakthrough ideas that only come from a diverse workforce empowered to challenge conventional thinking. We’re curious about science and the advancement of knowledge. We find creative ways to approach new challenges. We’re driven to make the right choices and be accountable for our actions. As an organisation centred around what makes us human, we put a big focus on people. Across our business, we want colleagues to wake up excited about their day at the office, in the field, or in the lab. Along with our purpose to bring life-changing medicines to people across the globe, we have a promise to you: to help you realise the full breadth of your potential. Here, you’ll do work that has the potential to change your life and improve countless others. And, together with your team, you’ll shape a culture that unites and inspires us every day. This is your life at AstraZeneca.

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