Welcome to Holly Springs, North Carolina— home to Roche/Genentech's largest-ever investment: a $2B greenfield start-up where next-generation technology, high-performing teams and Operational Excellence converge to create the global standard for high-volume, highly-efficient Drug Product manufacturing. The facility's core is defined by Innovation - leveraging advanced automation, robotics, digital tools, real-time data analytics, and simple, streamlined processes to produce the highest quality medicines. This plant meets today’s demand for CVRM (Cardiovascular, Renal, and Metabolism) medicines and is scalable to grow with the portfolio, which focuses on next-generation metabolic medicines specifically targeting the global obesity epidemic and Type 2 diabetes. This is a fast-paced, entrepreneurial environment with a high-level of accountability, with planned launch in 2028. Are you a problem-solver and change-agent who thrives in a Team environment, eager to tackle the most complex manufacturing challenges? If so, this is a once-in-a-lifetime opportunity to launch a state-of-the-art facility from the ground-up and shape the culture of our organization for the next generation. Join us in Holly Springs, where you won't just build a plant—you will build the future of medicine. The Opportunity This role is a vital component of our Site Engineering and Technology organization which is dedicated to ensuring seamless, safe, and fully compliant operations and facility services across our manufacturing facility. As a key member of this team, you will serve as a strategic leader bridging site executive leadership and external service partners to uphold our zero-business-disruption mission. In this role, you will collaborate closely with cross-functional partners in Manufacturing, Quality, Safety Health & Environment (SHE), and global network representatives to foster an inclusive "One Team" culture. As the Senior Manager, Facilities you will lead the strategic oversight of all Facility Management soft services, service partners and external cGMP service providers across our commercial manufacturing facility while directly owning key site facility compliance programs. These services will include (but not limited to), cafeteria services, janitorial, site spares/MRO store room, pest control You will serve as the primary liaison between site leadership and strategic vendor partners to drive operational excellence, inspection readiness, and continuous improvement in the facility. During the launch phase of the Greenfield build, you will develop the facility management strategy, onboard and setup service partners for the most reliable and quality service and optimal cost. You will ensure all facility services are set up on time, ready for when site occupancy transitions to commercial manufacturing. You will evaluate options for Integrated Facility Management (IFM) and setup an IFM program if the Post launch, you will manage these service providers and any IFM program oversight for the site. Strategic Provider Oversight: You will lead and manage the strategic relationship with the IFM provider and multiple outsourced personnel, ensuring hard and soft services meet rigorous quality, safety, and customer satisfaction standards. cGMP Compliance & Inspection Readiness: You will maintain direct ownership of key site programs—including GMP Cleaning, Facility Fitness, and Pest Control—ensuring total alignment with Roche global standards and full readiness for Health Authority audits. Frontline Operational Continuity: You will serve as a turnkey partner for Manufacturing Operations to ensure zero business disruptions while managing BCM (Business Continuity Management) capabilities and immediate vendor escalation pathways. Governance & Vendor Management: You will establish robust governance frameworks, lead L2 connectivity, host site KPI reviews, and manage vendor onboarding, training adherence, and employee/union relation escalations. Financial & Contractual Stewardship: You will oversee program budgets, audit and approve Service Change Requests (SCRs), identify contract risks, and drive financial efficiency through process simplification and innovation. Cross-Functional Collaboration: You will partner with site leadership, Quality, SHE, and global network teams to standardize processes, execute continuous improvement initiatives, and embody a collaborative "One Team" mindset. Who You Are: Education: You have a Bachelor’s degree in a technical field such as engineering, operations management, or a related discipline preferred. Bio-Pharma Experience: You have 8+ years of progressive experience within a bio-pharmaceutical manufacturing environment, with extensive hands-on experience in cGMP facilities. Facility & IFM Leadership: You have a proven track record leading facility and engineering operations, with deep technical expertise in managing Integrated Facilities Management (IFM) contract models and strategic service provider oversight. Technical Program Ownership: You have demonstrated capability in managing regulatory compliance and vendor performance for cGMP support functions (such as GMP cleaning, facility fit, maintenance/calibration, pest control, and validation). Leadership & Matrix Collaboration: You are a skilled leader with an entrepreneurial mindset who thrives in complex, matrixed organizations, exhibiting exceptional problem-solving abilities, inclusive team-building skills, and a commitment to psychological safety and continuous learning. The expected salary range for this position based on the primary location of Holly Springs, North Carolina is 119,000 - $222,000. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed in the link below. This is an on-site position. Relocation benefits are approved for this posting. Link to Benefits Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants. Who We Are Genentech, a member of the Roche group and founder of the biotechnology industry, is dedicated to pursuing groundbreaking science to discover and develop medicines for people with serious and life-threatening diseases. To solve the world's most complex health challenges, we ask bigger questions that challenge our industry and the boundaries of science to transform society. Our transformational discoveries include the first targeted antibody for cancer and the first medicine for primary progressive multiple sclerosis. The next step is yours. To apply today, click on the "Apply for this job" button. Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.

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