Why Join Intellia? Our mission is to develop curative genome editing treatments that can positively transform the lives of people living with severe and life-threatening diseases. Beyond our science, we live our four core values: One, Explore, Disrupt, Deliver and feel strongly that you can achieve more at Intellia. We have a single-minded determination to excel and succeed together. We believe in the power of curiosity and pushing boundaries. We welcome challenging thoughts and imagination to develop innovative solutions. And we know that patients are counting on us to make the promise a reality, so we must maintain high standards and get it done. We want all of our people to go beyond what is possible. We aren’t constrained by typical end rails, and we aren’t out to just “treat” people. We’re all in this for something more. We’re driven to cure and motivated for change. Just imagine the possibilities of what we can do together. How You Will Achieve More: As a successful candidate you will join the sgRNA Process Development Group as part of the larger Oligonucleotide and Lipid Process Sciences team within Technical Operations/CMC. As SME for the sgRNA upstream process and process chemistry you will be providing technical and operational support across all life-cycle stages for Intellia’s assets from emerging pipeline through commercial-stage activities. You will help drive process design, development, characterization and finally tech transfer of GMP-ready processes while serving as a key technical partner across cross-functional teams within Intellia and with external partners as needed. In this role you are expected to mentor junior staff and drive continuous improvement across our processes and operations. Responsibilities: Process Development & Technical Execution Lead development, optimization and characterization of solid-phase oligonucleotide synthesis (upstream focus), with emphasis on scalability and tech. transfer (OP100 scale) Design and execute process characterization studies/DoEs and troubleshoot analytical data Support downstream purification processes to improve yield, purity, and reproducibility Support MSAT team with tech transfer and process validation activities as well as continuous process verification as needed Operational Execution & Documentation Track milestones, dependencies, and risks across concurrent PD workstreams Manage day-to-day lab resourcing and prioritization Coordinate with external manufacturing & supply chain as well as CDMOs in support sgRNA and lipid manufacturing as needed Author and review SOPs, batch records, development reports, sections for regulatory filings as well as process validation and change control documentation Mentorship & Collaboration Represent Process Development and provide updates to cross-functional teams using effective communication to both technical and non-technical audiences Serve as the team process chemistry SME across the matrix for oligonucleotide and small molecule synthesis; mentor and train junior scientists; and collaborate with stakeholders that support other modalities. About You: Solid expertise in phosphoramidite and oligonucleotide process chemistry with hands-on experience in automated synthesizers (OP100, Oligosynt platforms) and HPLC Strong organic chemistry foundation with working knowledge in small molecule manufacturing processes is an advantage Proficiency in HPLC and LC-MS for oligonucleotide characterization and analytical troubleshooting Excellent technical writing skills; track record of authoring SOPs, reports, and regulatory documents. Being highly organized with ability to manage multiple concurrent workstreams and drive priorities independently PhD in Organic Chemistry, Biochemistry, Biotechnology, or related field MS or BS in a related scientific discipline Ph.D. or M.S. in Chemistry, Organic Chemistry, Nucleoside Chemistry or related discipline with minimum 2 (PhD) or 8 (M.S.) years' experience, preferably in oligonucleotide field. Hands-on experience with solid-phase oligonucleotide synthesis and operation of lab-scale synthesizers; familiarity with GxP operations, quality systems and the pharmaceutical development lifecycle Experience driving multiple workstreams internally with cross-functional stakeholders as well as with external partners #LI-On-Site EEOC Statement: Intellia believes in a diverse environment, and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Intellia will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Applications are accepted on a rolling basis, and will continue to be accepted until the position is filled at which point the position will be taken down. The base salary for this position is expected to range between $136,800.00 - $167,200.00 USD per year. The salary offered is determined based on a range of factors including, but not limited to, relevant education and training, overall related experience, specialized, rare or in-demand skill sets, internal comparators and other business needs. Upon joining Intellia, your salary will be reviewed periodically and additional factors such as time in role and performance will be considered. Intellia may change the published salary range based on company and market factors. Additional compensation includes a performance-based annual cash bonus, a new hire equity grant, and eligibility to be considered for annual equity awards the value of which are determined annually at the Company’s discretion. For more information about Intellia’s benefits, please click here. At Intellia, we are committed to solving the complex challenges of making CRISPR/Cas9-based medicines a reality for patients suffering from genetic diseases and to create novel engineered cell therapies for immuno-oncological and autoimmune diseases.

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