Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH. Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c). Our success is driven by our people. We are building a dynamic, inclusive, and high-performing culture that values scientific excellence, operational rigor, and collaboration. To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way. Reporting to the Executive Director, Tax, the Associate Director, U.S. Tax Operations & Reporting will be accountable for Madrigal’s U.S. tax operations and global tax reporting infrastructure, including ASC 740 tax reporting, U.S. compliance, financial statement and tax authority audit readiness, SOX-aligned controls, tax technology enablement, and external advisor management. This hands-on role requires a tax professional who can independently drive work from planning through execution, deliver audit-ready work product, bring clear recommendations to senior leadership, and translate complex tax matters into practical business guidance for Finance and business partners. Key Outcomes for Success Deliver accurate, timely, audit-ready quarterly and annual tax reporting under ASC 740, including the tax provision, UTPs, effective tax rate, Form 10-K/10-Q disclosures, and documentation supporting key judgments. Convert tax risks and technical analyses into concise recommendations, options, and decision points for senior leadership and business partners. Build capacity and operational leverage within the Tax function by leading external advisors and cross-functional workstreams with clear priorities, accountability, and continuous improvement. Establish a scalable, well-governed tax operating model that strengthens controls, improves efficiency, and supports the Company's continued growth. Advance the Tax function's technology and data capabilities by leveraging automation, system enhancements, and scalable digital solutions to improve efficiency, reporting accuracy, and business insights. Key Responsibilities Tax Provision and Financial Statements Own the quarterly and annual ASC 740 income tax provision process, including effective tax rate analysis, deferred tax inventory, valuation allowance assessment, uncertain tax positions, and tax-related balance sheet accounts. Direct the tax close calendar, deliverables, workpapers, review process, tax footnotes, disclosures, quarterly reviews, and annual audit support to deliver timely, accurate public company reporting. Own technical tax accounting conclusions for complex and non-routine matters, directing preparation of supporting memoranda and presenting recommendations to the Executive Director, Tax and Finance leadership. Drive alignment with Corporate Accounting, International Finance, FP&A, Treasury, and external auditors on forecasting, cash tax projections, reporting requirements, and key tax accounting judgments. U.S. Tax Compliance, Operations & Audit Support Oversee U.S. federal, state, local, Puerto Rico, and applicable indirect tax compliance processes, including estimated payments, extensions, returns, information reporting, and other required filings. Govern the tax compliance calendar, risk register, documentation protocols, escalation processes, and external service provider model to ensure deadlines are met, deliverables meet quality standards, and risks are visible early. Lead review of tax audit workpapers, information request responses, and supporting documentation to ensure technical accuracy, completeness, and alignment with Company tax positions; escalate judgment items and recommended responses to the Executive Director, Tax Team with advisors on execution for U.S. international tax reporting and related calculations, including Subpart F, GILTI/net CFC tested income, FDII/foreign-derived deduction-eligible income, foreign tax credits, transfer pricing inputs, and related compliance considerations. Drive R&D credit analysis, documentation, process coordination, and audit readiness in partnership with tax advisors and operational business stakeholders. Monitor legislative and regulatory developments and advise on impacts to the Company’s tax provision, compliance profile, cash taxes, and operational tax processes. Tax Technology, Controls & Process Infrastructure Establish and enhance tax controls, policies, process narratives, documentation, and operating procedures to support SOX compliance, audit readiness, and scalable public company reporting. Define tax requirements and lead tax implementation for ERP, tax provision, indirect tax, reporting, compliance tracking, and workflow automation initiatives in partnership with Accounting, IT, and external advisors. Define and execute process improvements that reduce manual processes, improve data quality, accelerate close and compliance timelines, and increase reliability of tax reporting outputs. Cross-Functional Business Advisory & Strategic Support Advise Finance and business leaders on tax reporting and operational matters, translating complex tax requirements into business impact, risk, tradeoffs, and recommended next steps Drive alignment with internal and external stakeholders to ensure transfer pricing policies, intercompany flows, and operational processes are implemented consistently and supported by appropriate documentation. Champion continuous improvement across the Tax function by identifying opportunities to simplify processes, strengthen governance, and enhance the effectiveness of tax operations through scalable solutions. Required & Desired Qualifications Bachelor’s degree in Accounting or a related field required; Master’s in Taxation or related advanced degree preferred; CPA required. 10+ years of progressive corporate tax experience, ideally including a combination of Big Four/public accounting and in-house public company multinational corporate tax experience. Deep expertise in public company ASC 740 income tax accounting, U.S. corporate taxation, financial statement disclosures, and tax-related SOX controls. Hands on experience leading complex quarterly and annual income tax provisions for multinational corporations, including ETR analysis, deferred taxes, valuation allowances, uncertain tax positions, and financial statement disclosures. Strong experience with U.S. federal, state, local, Puerto Rico, and indirect tax compliance, tax audit support and workpaper review, and U.S. international tax reporting and operational matters, including NCTI, FDDEI, FTCs, and related calculations. Experience with tax technology, ERP systems, and process automation initiatives; OneSource Tax Provision and indirect tax engine experience, such as Vertex or OneSource Indirect Tax, preferred. Proven ability to own technical tax analyses, manage external advisors and financial statement auditors, and communicate complex tax matters to senior leaders and non-tax stakeholders. Core Competencies Ownership and independent judgment: Leads complex, high-impact work with minimal oversight, synthesizes technical and business considerations into actionable recommendations, and exercises sound judgment in balancing risk, compliance, and business objectives. Operational Rigor: highly organized, deadline-driven, and able to manage multiple priorities without compromising quality. Communication: able to distill complex tax issues into concise business impact, options, recommendations, decisions needed, and timing. Leadership & Influence: Builds credibility and influences decisions across functions. Effectively aligns stakeholders, navigates competing priorities, and drives execution through collaboration, sound judgment, and executive presence. Strategic Thinking: Anticipates emerging risks and opportunities, evaluates long-term implications, and develops scalable solutions that support the Company's growth and evolving business needs. Madrigal’s Total Rewards strategy is based on a biotech industry peer group comparator and is inclusive of base pay, bonus and equity. Our equity offers meaningful opportunity allowing our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization. All employees receive equity, which we believe reinforces our ownership culture. Base salary is determined by several factors including the candidate’s qualifications, skills, education, experience, business needs and market demands. As of the date of this posting, a good faith estimate of the current pay scale for this position, applicable to all candidates, is $166,500 - $203,500 per year. We comply with all applicable minimum wage laws. All full-time employees receive equity, which reinforces our ownership culture and offers meaningful opportunity for our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization. Full-time employees are also eligible for comprehensive benefits, including flexible paid time off, medical, dental, vision and life/disability insurance, and 401(k) offerings (i.e., traditional, Roth, and employer match) in accordance with applicable plans. We also offer additional voluntary benefits like supplemental life insurance, legal services, and other offerings. In addition, we offer mental health benefits through our Employee Assistance Program for employees and their family. The company also provides other benefits in accordance with applicable federal, state, and local laws. We are committed to providing reasonable accommodations for individuals with disabilities throughout the hiring process. If you need assistance, please contact [email protected]. Madrigal is an Equal Opportunity Employer. All employment is decided on the basis of qualifications, merit, and business need. Applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex gender identity, sexual orientation, national origin, age, disability, protected veteran or disabled status, or other characteristic protected by applicable federal, state, or local law. Unsolicited resumes from agencies should not be forwarded to Madrigal. Madrigal will not be responsible for any fees arising from the use of resumes through this source. Madrigal will only pay a fee to agencies if a formal agreement between Madrigal and the agency has been established. Applications are being accepted on an ongoing basis and can be submitted through our Madrigal Careers site. Please be aware that we have received reports of individuals misrepresenting themselves as Madrigal Pharmaceuticals’ Hiring Managers, seeking to engage with job candidates through fraudulent online advertisements or job posting sites. These unauthorized individuals are using Madrigal’s name and logo in an attempt to solicit up-front fees and obtain personal information from interested job candidates. Please know that Madrigal does not conduct interviews via text or in chat rooms; conduct interviews via Skype, RingCentral or solely via telephone; charge candidates an advance fee of any kind (e.g., fees for purchasing equipment); nor does it offer positions of employment without undergoing a thorough recruiting process. Please also note that any correspondence with regard to employment would come from an authorized madrigalpharma.com email address or from an email address from one of our trusted search firm partners. We are aware that incorrect/fraudulent email addresses, with Madrigal misspelled, have been utilized in these most recent fraud attempts. If you receive unsolicited employment offers from people claiming to work for or on behalf of Madrigal, we recommend that you: do not respond to their questions; do not open any attachments; and do not click on any hyperlinks. Any questions regarding the legitimacy of job-related contacts can be directed to [email protected]. Join our growing team focused on transforming the treatment of people with liver diseases. Madrigal is an Equal Opportunity Employer. All employment is decided on the basis of qualifications, merit, and business need. Applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex gender identity, sexual orientation, national origin, age, disability, protected veteran or disabled status, or other characteristic protected by applicable federal, state, or local law.

Associate Director, U.S. Tax Operations & Reporting.

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