Health Economics Manager, CVRM London, Pancras Square Introduction to the role: Do you have expertise in and passion for access submissions? Would you like to apply your expertise in a company that follows the science and turns ideas into life changing medicines? Then AstraZeneca might be the one for you! As a Health Economics Manager in the Biopharmaceutical Business Unit (CVRM: Cardiovascular, Renal & Metabolic), you will lead the delivery of health economic content for national Health Technology Assessment (HTA) submissions. This is a hands-on modelling role: you will build, adapt, and own the cost-utility and budget impact models that convey the value of AstraZeneca medicines and help secure national-level patient access. Reporting to the Head of Market Access, CVRM, you will partner with the UK Market Access function, the Medical Directorate, Brand Marketing teams (as well as broader UK-based cross functional teams), and the Global Health Economics & Payer Evidence team. Accountabilities: - Develop, tailor, and deliver health economic analyses for health technology appraisals (75%) Cost-Utility and Budget Impact Modelling: Take a hands-on approach to tailoring final deliverables to UK HTA needs, including developing budget impact analyses and adapting cost-utility models in Microsoft Excel. Global HEOR Collaboration: Work with the global HEOR function to shape cost-utility analysis models, systematic literature reviews, network meta-analyses, and other payer-related materials for HTA. Strategic Input: Provide strategic input into pricing strategy, evidence needs, and related decisions. Prior Appraisal Research: Research prior appraisals to understand relevant considerations. Submissions: Write the cost-effectiveness sections for submissions to NICE, SMC, and AWMSG, working collaboratively with UK Market Access colleagues and the Medical team. Technical Responses: Provide high-quality responses to technical assessor questions, including model-related queries. Committee Representation: Represent AstraZeneca to a high standard at appraisal committee meetings. Outsourcing: Manage the outsourcing of some aspects, as needed. Ensure deliverables are of high quality. - Develop early cost-effectiveness analyses for future brands and indications (20%) Early Modelling: Build early cost-effectiveness models based on the target product profile to inform national market access feasibility assessments, support the internal forecasting process, and feed into global-led consultations. Prior Appraisal Research: Research prior appraisals to understand relevant considerations. - Business partnering on priority brands (5%) Brand and Therapy Area Knowledge: Develop strong brand and therapy area knowledge to support Brand Marketing Teams, taking the time to understand their needs. Cross-Functional Planning: Contribute to strategic and operational planning within cross-functional teams. - Performance indicators: HTA outcomes versus expectations, feedback from internal customers, and performance versus goals. Essential Requirements: Modelling Expertise (Key Requirement): Proven ability to develop cost-utility analysis and budget impact models in Microsoft Excel. VBA: Working knowledge (or above) of Microsoft VBA. Education: Postgraduate qualification in health economics. HTA Experience: 3+ years of experience developing HE content for HTA submissions, in either a HEOR agency or the pharmaceutical industry. Communication: Excellent interpersonal and communication skills, including strong written skills. Delivery and Collaboration: Demonstrable record of collaborative working and personal delivery to agreed timelines. Prioritization: Ability to prioritize effectively based on business need. Capability Building: Experience training non-Health Economists in the effective delivery of HE outputs. Desirable Requirements: Education: First degree in economics, life sciences, mathematics, or similar. Supplier Management: Experience managing external suppliers. Talent Development: Experience up-skilling junior HE staff. Broader Experience: Other experience beyond Health Economics (e.g., NHS). Therapy Area Experience: Experience in Cardiovascular, Renal & Metabolic therapy areas. When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world. Why AstraZeneca? At AstraZeneca we’re dedicated to being a phenomenal Place to Work. Where you are empowered to push the boundaries of science and fuel your ambitious spirit. There’s no better place to make a difference to medicine, patients and society. A broad culture that fosters diversity and teamwork, and always committed to lifelong learning, growth and development. We’re on an exciting journey to pioneer the future of healthcare. So, what’s next? If you are inspired by the possibilities of science to make a difference and ready to discover what you can do by joining us on this exciting journey and believe you can contribute to this bold ambition – join us! Where can I find out more? Our Social Media, Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/ Follow AstraZeneca on Facebook https://www.facebook.com/astrazenecacareers/ Follow AstraZeneca on Instagram https://www.instagram.com/astrazeneca_careers/?hl=en Date Posted 27-Oct-2026 Closing Date 09-Nov-2026 Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form. AstraZeneca is a global, science-led, patient-focused biopharmaceutical company. We focus on discovering, developing and commercialising prescription medicines for some of the world’s most serious diseases. But we are more than one of the world’s leading pharmaceutical companies. At AstraZeneca, we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science, challenge convention and unleash your entrepreneurial spirit. To embrace differences and take bold actions to drive the change needed to meet global healthcare and sustainability challenges. There is no better place to make a difference in medicine, patients, and society. An inclusive culture where you will connect different thinking to generate new and valuable opportunities. Where you will find a commitment to lifelong learning, growth and development for all. Our Inclusion & Diversity (I&D) mission is to create an inclusive and equitable environment where people belong, using the power of our diversity to push the boundaries of science to deliver life-changing medicines to patients. Inclusion and diversity are fundamental to the success of our company, because innovation requires breakthrough ideas that only come from a diverse workforce empowered to challenge conventional thinking. We’re curious about science and the advancement of knowledge. We find creative ways to approach new challenges. We’re driven to make the right choices and be accountable for our actions. As an organisation centred around what makes us human, we put a big focus on people. Across our business, we want colleagues to wake up excited about their day at the office, in the field, or in the lab. Along with our purpose to bring life-changing medicines to people across the globe, we have a promise to you: to help you realise the full breadth of your potential. Here, you’ll do work that has the potential to change your life and improve countless others. And, together with your team, you’ll shape a culture that unites and inspires us every day. This is your life at AstraZeneca.

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