Postdoctoral Fellow | Host-Microbiome Biology/ Organ-on-Chip Models Jalili Lab The Jackson Laboratory for Genomic Medicine, Farmington, CT Job description The Jalili lab at the Jackson Laboratory for Genomic Medicine is seeking a highly motivated postdoctoral fellow to join our team. The successful candidate will investigate how interactions between intestinal bacteria and patient-derived epithelial tissues shape cellular states, tissue function, and disease susceptibility. While colorectal cancer (CRC) will serve as a primary disease model, the research will address broader mechanistic questions related to cancer initiation and evolution, epithelial reprogramming, host-microbiome interactions, and aging. This work will involve using patient-derived human colon organoids and perfused, hypoxia-enabled colon-on-a-chip models with controlled host-microbe interactions through controlled bacterial-epithelial coculture, quantitative functional assays, and molecular profiling. By integrating advanced human tissue models with mechanistic studies, the research aims to identify and characterize host pathways that regulate epithelial responses to microbial interactions. This position is particularly well suited to an experimental scientist interested in bridging tissue engineering, cell and molecular biology, and host-microbiome research. Prior experience in organ-on-a-chip or microfluidic systems, bacterial-epithelial coculture, gastrointestinal biology, or cancer biology is highly desirable, while experience with molecular profiling and transcriptomic approaches is an advantage. The position also offers opportunities for interdisciplinary collaborations with clinician-scientists at Connecticut Children’s, bioengineers at the University of Connecticut, immunologists at UConn Health, and microbiome researchers at Duke University. JAX has a vibrant and interactive research and training environment characterized by multidisciplinary scientific collaboration, unparalleled mouse resources, and outstanding core services. In addition to lab-based training, JAX has developed a unique program for trainees to expand their professional skills in science communication, entrepreneurship, teaching, mentoring and laboratory management to best prepare postdocs for future career opportunities. JAX Genomic Medicine is located in the scenic town of Farmington, Connecticut, within 1.5-2 hour of Boston and New York City and with convenient access to major highways, rail networks, and international airports. Research responsibilities Establish, maintain, and characterize patient-derived human intestinal organoids, including nonmalignant and colorectal cancer tissues, and integrate organoid-derived epithelia into advanced microphysiological systems. Operate and optimize perfused, hypoxia-enabled gut-on-a-chip models to investigate epithelial function, differentiation, barrier integrity, and host-microbiome interactions. Design and conduct controlled bacterial-epithelial coculture experiments to investigate how microbial interactions influence epithelial cellular states, function, and disease-associated phenotypes. Apply cellular and molecular techniques, including microscopy, gene-expression analysis, and quantitative functional assays, to investigate epithelial responses, cellular plasticity, and underlying molecular mechanisms. Integrate functional studies with transcriptomic and other molecular profiling approaches to identify host pathways involved in epithelial regulation and disease susceptibility; contribute to scientific publications, grant applications, and collaborative research projects. Qualifications Ph.D. in bioengineering, microbiology, cell and molecular biology, cancer biology, or related field of study. Strong hands-on research experience in cell and tissue engineering, 3D organoid culture, primary epithelial cell culture, or microphysiological systems. Experience in organ-on-a-chip technologies, microfluidics, bacterial culture, or host-microbe coculture is highly desirable. Strong experimental background in cellular and molecular biology, including microscopy, immunofluorescence, gene-expression analysis, and quantitative functional assays. Prior research experience in gastrointestinal biology, host-microbiome interactions, cancer biology, epithelial plasticity, or aging is preferred. Experience with transcriptomics, multi-omics approaches, or in vivo models is an advantage. Candidates should have at least one 1st author publication record in peer-reviewed journal. Excellent writing and communication skills, able to work independently and effectively with other members in a productive team. To apply Interested candidates must submit all three application components listed below. Incomplete applications will not be considered. A cover letter summarizing research training and accomplishments A personal statement of scientific interests and career goals (1-page maximum) Current CV with publications and contact information of three references The Jalili lab supports postdocs that have either academic or non-academic long-term career goals, international candidates, women and candidates from all backgrounds. We truly believe in equal opportunity for all. JAX Salary: Year 0 - 1: $65,589 Year 1 - 2: $67,318 Year 2 - 3: $69,095 Year 3 - 4: $70,521 Year 4 - 5: $72,877 Year 5 - 6: $75,569 Based on years of experience as Postdoc About JAX: The Jackson Laboratory is an independent, nonprofit biomedical research institution with a National Cancer Institute-designated Cancer Center and nearly 3,000 employees in locations across the United States (Maine, Connecticut, California, New York, Florida), Japan and China. Its mission is to discover precise genomic solutions for disease and empower the global biomedical community in the shared quest to improve human health. Founded in 1929, JAX applies over nine decades of expertise in genetics to increase understanding of human disease, advancing treatments and cures for cancer, neurological and immune disorders, diabetes, aging and heart disease. It models and interprets genomic complexity, integrates basic research with clinical application, educates current and future scientists, and provides critical data, tools and services to the global biomedical community. For more information, please visit www.jax.org. EEO Statement: The Jackson Laboratory provides equal employment opportunities to all employees and applicants for employment in all job classifications without regard to race, color, religion, age, mental disability, physical disability, medical condition, gender, sexual orientation, genetic information, ancestry, marital status, national origin, veteran status, and other classifications protected by applicable state and local non-discrimination laws. Bar Harbor: The Jackson Laboratory's 43-acre scenic Bar Harbor campus is nestled between the Gulf of Maine and the mountains of Acadia National Park. Some of the best hiking and biking in the world (over 50 square miles of mountains, lakes, views, and dramatic coastline) is accessible from our campus. We are one mile from downtown Bar Harbor, which offers a vibrant downtown district with a plethora of restaurants, shops, museums, and galleries. Ellsworth: The Charles E. Hewett Center in Ellsworth, Maine, is a state-of-the-art facility that serves researchers world wide. The facility represents the culmination of nine decades of unmatched experience and leadership in breeding and caring for laboratory mice. Ellsworth, Maine, is one of Maine’s fastest growing cities. With a growth rate of nearly 20%, Ellsworth is a bustling year-round community and acts as a hub for surrounding towns. It is located nearby Acadia National Park and hosts numerous special events, concerts and festivals each year. Residents have access to fabulous shopping, recreation, museums, galleries, and dining at a variety of independent restaurants. Farmington: JAX Genomic Medicine is transforming medicine by improving patient care, lowering costs, and increasing life span and health span. JAX Genomic Medicine’s research focuses on the complex genetic causes of disease and on the development of genomic solutions tailored to each person's unique genetic makeup. JAX Genomic Medicine sits on a 17-acre site on the campus of the University of Connecticut Health Center. The 183,500-square-foot facility opened in the fall of 2014. Now, it houses over 300 biomedical researchers, technicians, and support staff in state-of-the-art computing facilities and laboratories. In Connecticut, JAX resides in the scenic town of Farmington, in the state’s capitol region. The Hartford region, which offers some of the best public schools in the country, is made up of both bigger cities and smaller, charming historic New England towns. JAX Genomic Medicine is also geographically located within 2 hours of Boston and New York and is close to multiple transportation systems, including bus lines, highways, railroads and international airports. Sacramento: The JAX® Mice, Clinical and Research Services facility is located in Sacramento, the state capital of California. Sacramento is less than a two-hour drive from San Francisco, Napa Valley, and scenic Lake Tahoe, and a short flight to both Los Angeles and Orange County. Sacramento is the birthplace of the nation’s Farm to Fork movement, and offers excellent restaurants, gastro-pubs, wineries, theaters, and museums. Outdoor activities are plentiful: Boating, white water rafting, and riding the scenic bicycle trails are popular. Housing and other costs of living are more affordable in Sacramento and its surrounding suburbs than in most other neighboring areas in the North Bay, making Sacramento one of the hottest housing markets in the country year after year. Augusta: JAX’s Maine Cancer Genomics Initiative (MCGI) is located in Augusta, Maine, in the Harold Alfond Center for Cancer Care (HACCC), at Maine General Hospital. It began operations in 2016 with three overarching goals: to provide cancer genomic testing for Maine cancer patients; to develop and deliver physician education about clinical genomic cancer diagnostics; and to build a network in Maine of oncology practices conducting studies in genomic medicine.

Postdoctoral Fellow | Host-Microbiome Biology/ Organ-on-Chip Models | Jalili Lab.

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