Job Description General Summary: The Senior Manager, Heme Patient Support Communications team member will be part of the Heme Patient Support Team within the Vertex Patient Support Business Unit. The Heme Patient Support Team is dedicated to providing end-to-end order management support for Authorized Treatment Centers (ATCs) and support for patients undergoing gene therapy for sickle cell disease (SCD) and transfusion dependent thalassemia (TDT). This individual will be become deeply familiar with the CASGEVY treatment journey and needs of key HCP & patient communities. Key Duties and Responsibilities: Clearly understand and compliantly support the needs of healthcare providers and patients undergoing treatment with CASGEVY Become deeply ingrained in the order management process at ATCs with a specific focus on the responsibilities and needs of cell and gene therapy coordinators, Apheresis teams, and transplanters In close collaboration with the Global Commercial Marketing team and Systems team, provide input and finalize order management materials and derivative training materials for ATCs Collaborate with Order Manager team lead and order managers to develop and execute resources including HCP/Patient conversation guides, tactical implementation guides, communications, and email templates Provide support for material development and communications for the Vertex Connects Patient Support Program Lead the development of manufacturing communication updates in collaboration with Manufacturing, Quality, and Legal partners Consult on systems updates to our HealthCloud CRM System and the Vertex Connects Portal Consult on development of relevant SOPs and Work Instructions as well as trainings and onboardings Manage review and approval process of materials with legal/medical/regulatory partners and ensure final pieces are appropriately uploaded to the CRM platform and re-approved bi-annually Manage external agency partners in the development, review, and approval of order management and ATC communications Ensure tactics are created on time & within budget Support annual brand planning efforts to think forward about program evolutions Knowledge and Skills: Ability to work in a fast paced, evolving environment Strong communication skills and interpersonal skills to guide others internally/externally; ability to inspire a team towards clear goals Ability to identify and resolve technical problems and to recognize opportunities for continuous improvement Patient-centric and customer service minded Ability to work as a team player in diverse settings/situations, including leading a team, collaborating on a lateral team and partnering on cross functional teams Appropriate judgment; consistency in decision making Expertise in product access and adherence Attention to detail and committed follow-through with stakeholders Education and Experience: Bachelor's degree, or equivalent combination of education and related work experience 6+ years of combined educational/work experience in any combination of the following: Communications or Marketing Operations experience in an industry setting, ideally supporting product or program launches Experience in Case Management in a clinical or industry setting Cell or gene therapy, or transplant experience in the clinical or industry setting Familiarity/experience working with the SCD and/or TDT communities At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients. Pay Range: $136,000 - $204,000 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time. #LI-Hybrid Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at [email protected] Help Us Achieve Our Mission Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases and conditions. The company has approved therapies for cystic fibrosis, sickle cell disease, transfusion-dependent beta thalassemia, acute pain and acromegaly, and it continues to advance clinical and research programs in these areas. Vertex also has a robust clinical pipeline of investigational therapies across a range of modalities in other serious diseases where it has deep insight into causal human biology, including IgA nephropathy, neuropathic pain, APOL1-mediated kidney disease, primary membranous nephropathy, congenital adrenal hyperplasia, ACTH-dependent Cushing's syndrome, autosomal dominant polycystic kidney disease, type 1 diabetes, generalized myasthenia gravis, and myotonic dystrophy type 1. Vertex was founded in 1989 and has its global headquarters in Boston, with international headquarters in London. Additionally, the company has research and development sites and commercial offices in North America, Europe, Australia, Latin America and the Middle East. Vertex is consistently recognized as one of the industry's top places to work, including 17 consecutive years on Science magazine's Top Employers list and one of Fortune’s 100 Best Companies to Work For. For company updates and to learn more about Vertex's history of innovation, visit www.vrtx.com or follow us on LinkedIn, Facebook, Instagram, YouTube, and X We believe our culture is one of Vertex’s greatest strengths and a key enabler of our ability to deliver transformative medicines for patients who need them. Rooted in innovation, purpose and collaboration, our culture empowers people to take smart risks, challenge conventional thinking and do their best work. The diversity of our people is central to that culture. By bringing together individuals with different backgrounds, experiences and perspectives, we foster an environment where new ideas thrive, better decisions are made and breakthrough innovation is possible. We are committed to creating a workplace where everyone feels valued, included and connected to our shared mission, because we know that our unique culture and the collective strength of our people are what set Vertex apart.

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