What You Will Do You will provide strategic and operational leadership for the combined Translational Medicine and Translational Science organizations, including oversight of translational medicine leads, translational research teams, and other related scientific capabilities across the portfolio. You will drive the development and execution of translational strategies that support target and indication prioritization, evidence generation, biomarker development, and scientific /clinical differentiation across programs. You will help create strong scientific and data narratives that support asset progression and strengthen the positioning of programs within the competitive landscape. This includes providing timely bioanalytics and diagnostics support and development. You will lead efforts to build a more connected and agile translational organization, strengthening integration across research and development and ensuring translational activities are initiated and executed at the appropriate stages of the pipeline. You will serve as the leader of a Translational Sciences Center of Excellence, overseeing and prioritizing ongoing and future translational initiatives while continuously improving platforms, processes, and scientific capabilities to enhance quality, speed, and impact. You will play a key role in portfolio strategy, including support for indication selection, human target validation, and evaluation of external innovation through business development, partnerships, and scientific collaborations. You will work closely with R&D, Business Development, Competitive Intelligence, and other cross-functional partners to align translational strategy with broader corporate and portfolio priorities. You will contribute to governance and enterprise decision-making through participation in key leadership and portfolio committees, bringing scientific insight and strategic perspective to research prioritization and pipeline discussions. You will also lead, mentor, and develop a high-performing team, fostering a culture of scientific excellence, innovation, collaboration, and accountability. Why This Role Matters This is a unique opportunity to define and elevate the translational medicine and translational science strategy for a portfolio focused on high-impact science and rare disease innovation. The role offers broad visibility, enterprise influence, and the opportunity to shape how translational insights support the advancement of innovative therapies from research through development. Essential Qualifications M.D., Ph.D., or equivalent in a relevant scientific or medical discipline Significant leadership experience in translational medicine, translational science, drug discovery, and development, typically 15+ years Demonstrated success leading large cross-functional and matrixed teams in a complex organizational environment Deep understanding of how translational strategy supports program progression, scientific differentiation, and portfolio decision-making Experience connecting discovery, translational research, and development to support therapeutic advancement Strong scientific background in disease biology, biomarkers, diagnostics and translational approaches across multiple therapeutic areas Experience contributing to regulatory interactions, scientific documentation, and evidence-generation strategy Fluent in the potential of artificial intelligence to enhance and accelerate the process of drug development Excellent communication, leadership, and influencing skills, with the ability to engage effectively across scientific and executive audiences Desirable Qualifications Experience in rare disease drug development Track record of productivity as illustrated by publications, patents and regulatory filings Experience supporting business development, scientific diligence, portfolio evaluation, or external collaborations Experience building or scaling translational capabilities, platforms, or centers of excellence within a research and development organization Well networked with external stakeholders Leadership Profile The ideal candidate will bring scientific depth, strategic agility, and executive presence. You will be a collaborative, forward-looking leader who can inspire teams, influence across a matrixed organization, and translate scientific complexity into clear strategic direction. You should be recognized for your ability to build strong partnerships, develop talent, and lead through both vision and execution. Working Conditions The duties of this role are generally conducted in an office environment. As is typical of an office-based role, employees must be able, with or without accommodation, to use a computer, communicate via phone, video, and electronic messaging, engage in analysis and problem solving, collaborate with others, and maintain general availability during standard business hours. The annual base pay for this position ranges from $336.785,60 to $505.178,40. Hourly and salaried non-exempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles), to receive a retirement contribution (hourly roles), and commission payment eligibility (sales roles). Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base pay (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors. Date Posted 11-nov-2026 Closing Date 14-dic-2026 Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form. AstraZeneca is a global, science-led, patient-focused biopharmaceutical company. We focus on discovering, developing and commercialising prescription medicines for some of the world’s most serious diseases. But we are more than one of the world’s leading pharmaceutical companies. At AstraZeneca, we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science, challenge convention and unleash your entrepreneurial spirit. To embrace differences and take bold actions to drive the change needed to meet global healthcare and sustainability challenges. There is no better place to make a difference in medicine, patients, and society. An inclusive culture where you will connect different thinking to generate new and valuable opportunities. Where you will find a commitment to lifelong learning, growth and development for all. Our Inclusion & Diversity (I&D) mission is to create an inclusive and equitable environment where people belong, using the power of our diversity to push the boundaries of science to deliver life-changing medicines to patients. Inclusion and diversity are fundamental to the success of our company, because innovation requires breakthrough ideas that only come from a diverse workforce empowered to challenge conventional thinking. We’re curious about science and the advancement of knowledge. We find creative ways to approach new challenges. We’re driven to make the right choices and be accountable for our actions. As an organisation centred around what makes us human, we put a big focus on people. Across our business, we want colleagues to wake up excited about their day at the office, in the field, or in the lab. Along with our purpose to bring life-changing medicines to people across the globe, we have a promise to you: to help you realise the full breadth of your potential. Here, you’ll do work that has the potential to change your life and improve countless others. And, together with your team, you’ll shape a culture that unites and inspires us every day. This is your life at AstraZeneca.

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