The Executive Director, Head of US Rare Endocrinology and Rare Tumors will provide senior medical leadership and full US Medical Affairs strategic ownership for all in-country Medical Affairs activities for Alexion's Rare Endocrinology and Rare Tumors portfolio. This leader will define and implement the portfolio-wide US Medical Affairs strategy across marketed products, pipeline assets, launch readiness, indication expansion, and lifecycle management initiatives, ensuring alignment with Global Medical Affairs strategy, US business priorities, and patient-centered objectives. You will be responsible for: Advance understanding of the US Rare Endocrinology and Rare Tumors medical and treatment landscape, including evolving standards of care, unmet patient needs, evidence gaps, external expert perspectives, and emerging scientific developments, to inform the development and implementation of appropriate US Medical Affairs strategies aligned with Global Medical Affairs priorities. Lead the design and execution of the strategy and tactical plans for assigned tumors, aligned with Global strategy and US priorities. Serve as the senior US medical leader for the therapeutic area, including representation in US leadership forums, global governance discussions, and cross-functional portfolio planning. Lead and develop a high-performing Medical Affairs team, including Medical Directors, Regional MSL Directors, Medical Science Liaisons, and other therapeutic area team members as applicable. Define portfolio priorities, resource needs, and budget planning across the Tumor areas, ensuring trade-off decisions are clearly linked to patient impact, evidence gaps, launch priorities, and business-critical achievements. Partner closely with Commercial, Market Access, HEOR, Regulatory, Clinical Development, Medical Operations, Patient Advocacy, and Global Medical Affairs to ensure cross-functional alignment and combined planning activities. Provide leadership for launch readiness, lifecycle management, and evidence generation activities, including identification of data gaps and prioritization of real-world evidence, investigator-sponsored research, and company-sponsored research opportunities. Lead monthly and quarterly reviews of US Medical Affairs activities, including field medical performance, medical insights, evidence generation progress, and tactical plan execution. Ensure timely and high-quality publication planning and medical communication activities in support of Global and US Medical Affairs strategy. Drive scientific exchange strategy, advisory boards, congress engagement, thought leader development, and external expert engagement across relevant rare disease communities. Collaborate with HEOR and other partners to translate medical insights and evidence gaps into strategic actions that support improved patient care and outcomes. Partner with Global Medical Education and internal scientific training teams to localize and develop medical content for field medical scientific exchange and cross-functional education. Ensure medically accurate, scientifically balanced, compliant content review processes for promotional and non-promotional materials, as appropriate for the role. Drive the strategic adoption of AI and digital innovation within the Rare Endocrinology and Rare Tumors Medical Affairs organization. Identify training and development needs in collaboration with key partners and ensure implementation of medical training programs for field medical teams and other team members as appropriate. You will need to have: Advanced scientific or clinical degree, including M.D., PharmD, Ph.D., or equivalent advanced degree. Minimum of 12+ years of biopharmaceutical industry experience, with significant Medical Affairs leadership responsibility. Minimum of 10+ years leading and managing teams, including Medical Affairs organizations. Demonstrated experience developing and implementing medical strategy across multiple assets, indications, or stages of the product lifecycle, including marketed and pipeline assets. Rare disease experience, with endocrinology, oncology, rare tumors, or related therapeutic area experience strongly preferred. Demonstrated ability to influence senior leaders, external experts, and cross-functional partners while advancing medical strategies that improve patient care and outcomes. Demonstrated ability to employ digital, data, and AI-enabled capabilities to improve organizational effectiveness, accelerate decision making, and enhance Medical Affairs impact. We would prefer for you to have: Product lifecycle management, launch readiness, and indication expansion experience. Experience in early and late clinical development, evidence generation, real-world evidence, and/or investigator-sponsored research. Experience representing a therapeutic area in senior leadership forums, global governance discussions, major congresses, professional societies, advocacy engagements, or external scientific forums. Experience leading Medical Affairs strategy in a rare disease portfolio with small patient populations, complex diagnostic pathways, and specialized centers of excellence. When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world. If this role sparks your interest and you are ready to help shape the future of healthcare, apply now to join AstraZeneca’s journey of turning science into real impact for patients. The annual base pay for this position ranges from $ 282,046.40 - 423,069.60 Annual USD. Base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program. Benefits offered include a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base pay (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors. Date Posted 10-Nov-2026 Closing Date 24-Nov-2026 Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form. For over three decades, patients and their caregivers have been at the center of everything we do. Every day, we are inspired to follow the science and think differently to create better outcomes for them and their families. Our mission is driven by understanding who they are as unique individuals, not solely defined by their diseases. We’re a leading rare disease company with a diversified projects. Our pioneering legacy in rare diseases is rooted in being the first to translate the complex biology of the complement system into transformative medicines over the past three decades. Today, we continue to push the boundaries of science and deepen our understanding of rare diseases with patient-centricity at the core. This knowledge allows us to innovate and evolve into new areas where needs are unmet and provide an opportunity to help people fully live their best lives.

Executive Director, Head of US Rare Endocrinology and Rare Tumors.

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