Job Description Company Overview Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases. We are committed to advancing therapies that improve patients’ lives while fostering an inclusive, collaborative, and high-performing culture. At Vertex, talented teams work at the intersection of science, technology, and business to address complex challenges and deliver meaningful impact for patients around the world. Role Summary Vertex is entering an exciting phase of commercial diversification. As we expand into new pipeline disease areas and new geographies, we are investing in data, technology, and AI to scale commercial operations globally. The Commercial, Medical and External Affairs Technology team is expanding our capabilities with increased investment in data, platforms, and AI. The Commercial AI Product Management team leads a portfolio of high-value AI products that help accelerate commercialization, improve decision-making, simplify operations, and strengthen customer and patient engagement. The team connects business priorities with responsible AI capability development, product delivery, adoption, and value realization across Commercial, Medical Affairs, External Affairs, and partner functions. The Associate Director, AI UX Design is responsible for user discovery and end-to-end experience design for AI-enabled products supporting Commercial, Medical Affairs, and External Affairs across US and International markets. The role develops a deep understanding of users, workflows, and pain points and translates those insights into intuitive, accessible, trustworthy, and effective product experiences. Key Duties & Responsibilities Plan and conduct user discovery through interviews, observation, workshops, surveys, usability studies, and feedback and usage analysis. Synthesize research into insights, user groups, journey maps, workflow models, design principles, and prioritized experience opportunities. Partner with product owners and business stakeholders to frame problems, test assumptions, define outcomes, and inform strategy and roadmap decisions. Design end-to-end workflows and interaction models for AI-assisted, conversational, decision-support, and agent-based experiences. Create sketches, wireframes, prototypes, interface designs, and specifications to communicate and implement the intended experience. Plan and conduct concept and usability testing with representative users across U.S. and international markets. Design transparency, user control, review, escalation, correction, and error-recovery mechanisms for AI-enabled experiences. Partner with engineering, architecture, data science, product, analytics, and adoption teams to ensure designs are feasible, measurable, and continuously improved. Apply design systems and define reusable AI experience patterns that address accessibility, localization, device, channel, role, and market needs. Define and monitor experience measures such as task success, usability, user confidence, satisfaction, adoption, and friction. Required Education & Experience Bachelor’s degree in interaction design, HCI, UX design, design research, psychology, cognitive science, or a related discipline. Typically requires 8 years of experience in UX, product design, service design, user research, interaction design, or a related field, or equivalent education and experience. Experience conducting user discovery and delivering complex enterprise digital products from concept through implementation is required. Required Knowledge/Skills Advanced knowledge of user-centered design, design thinking, research, interaction design, information architecture, prototyping, and usability testing. Ability to conduct qualitative and quantitative research and translate findings into product and design decisions. Ability to design complex workflows and simplify technical capabilities for business users. Knowledge of AI experience considerations, including transparency, trust, user control, uncertainty, review, feedback, and error recovery. Proficiency with contemporary experience-design, prototyping, collaboration, and research tools. Knowledge of accessibility, inclusive design, responsive design, localization, content design, and design systems. Ability to communicate research findings and design rationale to business, technical, and executive audiences. Strong facilitation, collaboration, stakeholder management, and influencing skills. Ability to work effectively within technical, regulatory, privacy, and policy constraints. Proactive, organized, and comfortable managing shifting priorities in a fast-changing environment. Other Requirements A portfolio demonstrating user discovery, synthesis, workflow design, prototyping, usability testing, and delivered digital experiences is required. This role is expected to work on-site or in a hybrid arrangement in accordance with Vertex policies and business requirements. #LI-HYBRID At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients. Pay Range: $177,600 - $266,400 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time. #LI-Hybrid Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at [email protected] Help Us Achieve Our Mission Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases and conditions. The company has approved therapies for cystic fibrosis, sickle cell disease, transfusion-dependent beta thalassemia, acute pain and acromegaly, and it continues to advance clinical and research programs in these areas. Vertex also has a robust clinical pipeline of investigational therapies across a range of modalities in other serious diseases where it has deep insight into causal human biology, including IgA nephropathy, neuropathic pain, APOL1-mediated kidney disease, primary membranous nephropathy, congenital adrenal hyperplasia, ACTH-dependent Cushing's syndrome, autosomal dominant polycystic kidney disease, type 1 diabetes, generalized myasthenia gravis, and myotonic dystrophy type 1. Vertex was founded in 1989 and has its global headquarters in Boston, with international headquarters in London. Additionally, the company has research and development sites and commercial offices in North America, Europe, Australia, Latin America and the Middle East. Vertex is consistently recognized as one of the industry's top places to work, including 17 consecutive years on Science magazine's Top Employers list and one of Fortune’s 100 Best Companies to Work For. For company updates and to learn more about Vertex's history of innovation, visit www.vrtx.com or follow us on LinkedIn, Facebook, Instagram, YouTube, and X We believe our culture is one of Vertex’s greatest strengths and a key enabler of our ability to deliver transformative medicines for patients who need them. Rooted in innovation, purpose and collaboration, our culture empowers people to take smart risks, challenge conventional thinking and do their best work. The diversity of our people is central to that culture. By bringing together individuals with different backgrounds, experiences and perspectives, we foster an environment where new ideas thrive, better decisions are made and breakthrough innovation is possible. We are committed to creating a workplace where everyone feels valued, included and connected to our shared mission, because we know that our unique culture and the collective strength of our people are what set Vertex apart.

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