Job Description General Summary: The Toxicology Senior Research Fellow acts as the Preclinical Safety Assessment (PSA) lead on Research project teams, cross-site teams and steering committees and is accountable for overall project and often disease area and/or site strategy supporting safety assessment of novel molecules and therapies advancing through the Vertex discovery pipeline into early development. The key scientific individual contributor functions as part of cross-functional project teams and designs appropriate safety in vivo and in vitro safety studies to support advancement of project compounds/therapies to the candidate nomination stage. The incumbent is also accountable for site safety strategy and plays an integrated role in research site scientific leadership. This is a San Diego based, hybrid position requiring 3 days/week onsite. Key Duties and Responsibilities: Develops a broad and deep understanding of the disease area, target biology and chemical space for all Research programs at our San Diego site. Applies insight and knowledge to influence research strategy and target selection. Independently develops the strategy for early safety assessment and support for multiple programs from target selection into development and aligns with PSA leadership Collaborates with cross-functional and cross-site partners to develop safety strategies tailored to the portfolio at their resident site. Acts as a liaison between the project teams and other PSA subfunctions to arrange required studies and profiling assays and communicates results to the project team and site management with appropriate interpretation. Works with PSA study monitors to provide scientific oversight of external studies at CROs/partner organizations and communicates significant findings and study events to supervisors and PSA leadership in a timely manner. Collaborates closely with the program regulatory toxicologists to ensure a smooth transition from research into development Prepares high quality reports and presentations to clearly communicate study plans and results to peers, management and project teams Keeps up to date with current literature and emerging industry trends in general pharmaceutical toxicology and therapeutics. Participates in relevant continuing education activities and drives own professional development. Acts as an opinion leader and mentor to other toxicologists and cross-disciplinary research scientists. Knowledge and Skills: Subject matter expertise in small molecule toxicology and the design and interpretation of in vivo studies in common preclinical species In-depth knowledge of animal husbandry and animal welfare issues Excellent data processing and statistical skills Excellent written, verbal communications and influencing skills Microsoft Office Suite or equivalent office productivity tools DABT certification preferred Education and Experience: Bachelor’s, Master’s or Doctoral degree in life sciences or chemistry Typically requires a Bachelors degree and 20 years experience or Typically requires a Masters degree and 15 years experience or Typically requires a PhD and 11 years experience #LI-KM1 #LI-Hybrid At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients. Pay Range: $232,000 - $348,000 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time. #LI-Hybrid Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com Help Us Achieve Our Mission Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases and conditions. The company has approved therapies for cystic fibrosis, sickle cell disease, transfusion-dependent beta thalassemia, acute pain and acromegaly, and it continues to advance clinical and research programs in these areas. Vertex also has a robust clinical pipeline of investigational therapies across a range of modalities in other serious diseases where it has deep insight into causal human biology, including IgA nephropathy, neuropathic pain, APOL1-mediated kidney disease, primary membranous nephropathy, congenital adrenal hyperplasia, ACTH-dependent Cushing's syndrome, autosomal dominant polycystic kidney disease, type 1 diabetes, generalized myasthenia gravis, and myotonic dystrophy type 1. Vertex was founded in 1989 and has its global headquarters in Boston, with international headquarters in London. Additionally, the company has research and development sites and commercial offices in North America, Europe, Australia, Latin America and the Middle East. Vertex is consistently recognized as one of the industry's top places to work, including 16 consecutive years on Science magazine's Top Employers list and one of Fortune’s 100 Best Companies to Work For. For company updates and to learn more about Vertex's history of innovation, visit www.vrtx.com or follow us on LinkedIn, Facebook, Instagram, YouTube, and X We believe our culture is one of Vertex’s greatest strengths and a key enabler of our ability to deliver transformative medicines for patients who need them. Rooted in innovation, purpose and collaboration, our culture empowers people to take smart risks, challenge conventional thinking and do their best work. The diversity of our people is central to that culture. By bringing together individuals with different backgrounds, experiences and perspectives, we foster an environment where new ideas thrive, better decisions are made and breakthrough innovation is possible. We are committed to creating a workplace where everyone feels valued, included and connected to our shared mission, because we know that our unique culture and the collective strength of our people are what set Vertex apart.

Toxicology Senior Research Fellow.

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