Job Description Vertex is seeking a strategic and collaborative marketing professional to join our US Kidney Business Unit to support our aspirations of bringing Povetacicept to patients, a Phase 3 investigational therapy that has the potential to transform lives across multiple serious diseases. The Senior Marketing Manager, US Kidney - Pove will lead the strategic execution for the HCP marketing team alongside The US Kidney marketing team, which is preparing for potential commercialization of an investigational therapeutic being studied for the treatment of Immunoglobulin A nephropathy (IgAN) and other B cell-mediated diseases. This individual will lead the development and execution of marketing strategies and tactics aimed at healthcare professionals (HCPs) to drive awareness, education, and adoption of Vertex’s innovative therapies in the kidney disease space. The ideal candidate will bring deep experience in HCP marketing, strong cross-functional leadership, and a passion for improving patient outcomes in nephrology. This role reports to the Director, Head of HCP Pove Marketing for the US Kidney Business Unit and is based in Boston, MA. Responsibilities The Marketing Senior Manager will support the delivery of the marketing strategy by overseeing development of HCP tactics, and ensuring those tactics are delivered to customers effectively and monitored for effectiveness. Develops and updates marketing materials which are aligned with marketing strategy and business objectives (including branded websites, interactive visual aids, sales brochures, etc.) Translate scientific and clinical insights into compelling, compliant HCP messaging and materials. Analyzes complex digital and print material usage metrics for performance reporting and assessing needs for future updates across brands Manages agency partners to ensure budget is not exceeded and timely deliverables are executed Collaborates with brand leaders to ensure metrics are in place to measure the impact of tactics in field Drives assets through internal Communications Review Committee process Collaborate cross-functionally with the field, Medical Affairs, Patient Marketing, and disease education counterparts Ensure consistency of messaging across channels and touchpoints, tailoring communications to HCP needs and practice settings. Required Knowledge / Skills Ability to understand all elements of brand strategy and role in executing that strategy Broad understanding of regulatory rules and regulations with direct experience with communications review committee for review of tactics Exhibits ownership and broad accountability for projects and internal assignments; understand when it is appropriate to flag issues to management Ability to understand insights and the implications, and apply those insights to tactics, business problems, and opportunities Experience in pharmaceutical marketing, or closely related field(s) (e.g., pharmaceutical sales, ad agency, etc.) Required Education and Experience Bachelor’s degree required; advanced degree (MBA, MPH, PharmD, or similar) preferred. Typically requires 6+ years marketing, consulting or agency experience in healthcare / biopharmaceuticals and demonstrated supervisory / management experience, or an equivalent combination of experience and education Additional preferred experiences: Specialty product launch experience Work within highly competitive markets Kidney experience #LI-KW1 At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients. Pay Range: $140,000 - $210,000 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time. #LI-Hybrid Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com Help Us Achieve Our Mission Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases and conditions. The company has approved therapies for cystic fibrosis, sickle cell disease, transfusion-dependent beta thalassemia, acute pain and acromegaly, and it continues to advance clinical and research programs in these areas. Vertex also has a robust clinical pipeline of investigational therapies across a range of modalities in other serious diseases where it has deep insight into causal human biology, including IgA nephropathy, neuropathic pain, APOL1-mediated kidney disease, primary membranous nephropathy, congenital adrenal hyperplasia, ACTH-dependent Cushing's syndrome, autosomal dominant polycystic kidney disease, type 1 diabetes, generalized myasthenia gravis, and myotonic dystrophy type 1. Vertex was founded in 1989 and has its global headquarters in Boston, with international headquarters in London. Additionally, the company has research and development sites and commercial offices in North America, Europe, Australia, Latin America and the Middle East. Vertex is consistently recognized as one of the industry's top places to work, including 16 consecutive years on Science magazine's Top Employers list and one of Fortune’s 100 Best Companies to Work For. For company updates and to learn more about Vertex's history of innovation, visit www.vrtx.com or follow us on LinkedIn, Facebook, Instagram, YouTube, and X We believe our culture is one of Vertex’s greatest strengths and a key enabler of our ability to deliver transformative medicines for patients who need them. Rooted in innovation, purpose and collaboration, our culture empowers people to take smart risks, challenge conventional thinking and do their best work. The diversity of our people is central to that culture. By bringing together individuals with different backgrounds, experiences and perspectives, we foster an environment where new ideas thrive, better decisions are made and breakthrough innovation is possible. We are committed to creating a workplace where everyone feels valued, included and connected to our shared mission, because we know that our unique culture and the collective strength of our people are what set Vertex apart.

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