Passionate about precision medicine and advancing the healthcare industry? Recent advancements in underlying technology have finally made it possible for AI to impact clinical care in a meaningful way. Tempus' proprietary platform connects an entire ecosystem of real-world evidence to deliver real-time, actionable insights to physicians, providing critical information about the right treatments for the right patients, at the right time. About Tempus Tempus is on a mission to create the world’s largest integrated dataset of clinical and molecular data. We believe that, through data, we can make a lasting contribution to cancer research and treatment. At Tempus, products are owned and developed by small, autonomous teams of developers, designers, data scientists, and product managers who work together to build a platform that is both nimble and innovative. The Role As Senior Manager, Software Engineering, you will lead and mentor a small team of data engineers and data architects, and you will own the enterprise data model and the reliability of the data it represents. You will design how clinical records, genomics, next-generation sequencing (NGS) laboratory data, and radiology data are integrated, and you will ensure that the data are accurate, traceable, and suitable for critical applications such as machine learning and clinical decision-making. You will establish modeling standards, implement quality gates in data pipelines, and develop the team through design review, code review, and ongoing coaching. You will use development tools assisted by artificial intelligence (AI) to accelerate design, testing, and delivery. What You Will Do Lead and mentor a small team of data engineers and data architects by conducting design and code reviews, providing technical guidance, and fostering a culture of excellence in data architecture and data quality. Own and evolve an enterprise data model with engineers, product managers, scientists, and operators, integrating structured data from clinical records, genomics, the NGS laboratory, and radiology across relational and NoSQL data stores. Author and maintain entity-relationship diagrams, data dictionaries, API specifications, and data-translation documentation at the conceptual, logical, and physical levels. Apply modern data architecture best practices and patterns, and teach modeling standards, including third normal form, dimensional (star schema) design, and established healthcare data model standards such as FHIR, OMOP, and related standards. Evaluate the completeness of source-system models and partner data through profiling, and resolve structural inconsistencies before they reach downstream consumers. Design observability for the data ecosystem with BigQuery, dbt, Elementary, and Grafana, including monitors, alerts, dashboards, lineage, and traceability back to source systems. Partner with product managers and engineering leads to prioritize the backlog, estimate work, and translate complex requirements into actionable technical tasks. Advance the use of AI-assisted development, including Cursor, Claude, and GitHub Copilot, to accelerate modeling, testing, refactoring, and pipeline development. Why We Are Looking for You You have a record of leading and mentoring a small team of data engineers and data architects, of setting standards, and of guiding design in a fast-paced environment. You can translate gaps in the data model and in data quality into clear recommendations for engineers, scientists, and other stakeholders. You are an expert in the modern data stack, particularly dbt, SQL, and Python, and you have demonstrated exceptional SQL skills in an enterprise data warehouse. You are proficient in the use of AI coding assistants such as Cursor, Claude, and GitHub Copilot. You have applied modern data architecture best practices and patterns, and you can guide a team in their use. You have strong experience with third normal form (3NF) and dimensional (star schema) modeling; with established healthcare data model standards such as FHIR, OMOP, and related standards; and with modeling tools such as Erwin, Vertabelo, or Lucidchart. You understand ETL/ELT and business intelligence (BI) architectures, and you can explain the long-term implications of choosing among relational, massively parallel processing (MPP), and NoSQL technologies. You have architected solutions across more than one of these technologies. You have practical experience with data observability (for example, Elementary and Grafana) and with profiling and correlation analysis to identify data-integrity problems. You have domain experience in healthcare and next-generation sequencing, including clinical and genomic data. Preferred Deep knowledge of Google Cloud Platform (GCP) and BigQuery architecture. Experience modeling NGS data output. Experience in implementing master data, reference data, or metadata management. Why Join Tempus You will work at the intersection of software engineering and cancer research. In this role, you will lead a small team of data engineers and data architects and shape the data model and quality systems that make Tempus data reliable enough for research and clinical use. $150,000 - $225,000 The expected salary range may vary for other locations. Actual salary may vary based on qualifications and experience. Tempus offers a full range of benefits, which may include incentive compensation, restricted stock units, medical and other benefits depending on the position. We are an equal opportunity employer. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status. Ambry Genetics Corporation is a CAP-accredited and CLIA-licensed molecular genetics laboratory based in Aliso Viejo, California. We are a genetics-based healthcare company that is dedicated to open scientific exchange so we can work together to understand and treat all human disease faster. At Ambry, everyone is welcome. A career at Ambry Genetics is a chance to be part of a dynamic company that aims to improve health by understanding the relationships between genetics and human disease. We earned our reputation as industry leaders by responsibly introducing cutting-edge genetic testing solutions and continually sharing what we learn with the global scientific community. At Ambry you will be learning, challenging yourself, and having fun while collaborating with teammates through the open exchange of ideas. Our outstanding benefits program includes medical, dental, vision, FSA, paid sick leave and generous paid time off (PTO) program. The Company reserves the right to make changes to the 401k plan from time to time. You can learn more about the benefits here. Ambry Genetics is an Equal Opportunity Employer (EOE) and we maintain a drug-free work environment. The Company believes in second chance employment. Qualified applicants with arrest or conviction history will be considered regardless of their arrest or conviction history, consistent with local laws such as Los Angeles County Fair Chance Ordinance and the California Fair Chance Act. You do not need to disclose your criminal history or participate in a background check until a conditional job offer is made to you. After making a conditional offer and running a background check, if the Company is concerned about conviction that is directly related to the job, you will be given the chance to explain the circumstances surrounding the conviction, provide mitigating evidence, or challenge the accuracy of the background report. For the purpose of the above job description, “Essential Functions” are “Material Job Duties”. Our salary ranges are determined by role, level, and location. The range displayed on each job posting reflects the minimum and maximum target for new hire salaries for the position across all US locations. Within the range, individual pay is determined by work location and additional factors, including job-related skills, experience, and relevant education or training. All qualified applicants will receive consideration for employment without regard to race (and traits historically associated with race, including, but not limited to hair texture and protective hairstyles such as braids, locks, and twists), color, creed, religion, sex, sexual orientation, gender identity, gender expression (including transgender status), national origin, ancestry, age, marital status or protected veteran status and will not be discriminated against on the basis of disability, protected medical condition as defined by applicable state or local law, genetic information, or any other characteristic protected by applicable federal, state, or local laws and ordinances. If you have a disability or special need that requires accommodation, please contact us at [email protected] Ambry does not accept unsolicited resumes from individual recruiters, third party recruiting agencies, outside recruiters or firms without an executed contract in place. We are not responsible for any fees related to resumes that are unsolicited or are received by Ambry. Such resumes will be deemed the sole property of Ambry and will be processed accordingly. To review Ambry’s Privacy Notice, click here: Ambry’s Privacy Notice To review the California privacy notice, click here: California Privacy Notice | Ambry Genetics

Senior Manager, Software Engineering (Data Architecture).

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