Scientist II, Bioinformatics (Applications Lab) OPPORTUNITY PacBio is advancing highly accurate long-read sequencing to enable new discoveries and applications in genomics research and genetic testing. We are seeking a Scientist II, Bioinformatics to join our Applications Lab and support production and proof-of-concept sequencing projects. This role will focus on developing and maintaining computational infrastructure, automating data processing workflows, and delivering high-quality bioinformatics analyses for internal and customer projects. ABOUT THE ROLE As Scientist II, Bioinformatics, you will be a member of PacBio's Applications Lab, an internal customer and services laboratory that supports product development, customer evaluations, and commercial opportunities. You will be responsible for bioinformatics analyses for internal and customer projects, collaborating with laboratory scientists, Product Management, Marketing, and Sales teams to deliver results that demonstrate the capabilities and value of PacBio technology. You will also maintain the computational tools and infrastructure needed for laboratory operations, collaborating with laboratory scientists and Information Technology. This includes sample and project tracking, data organization, and automated analysis workflows. This is a hands-on role requiring strong programming skills, scientific expertise, and the ability to independently troubleshoot complex technical problems. RESPONSIBILITIES Sequencing lab project support: Collaborate with laboratory scientists to support sequencing projects, ensuring reliable data processing, analysis execution, and timely delivery of results. Bioinformatics analysis: Analyze PacBio sequencing data for internal projects, customer evaluations, and proof-of-concept studies. Deliver accurate results, visualizations, and summaries to scientific and commercial stakeholders. Laboratory computational infrastructure maintenance: Maintain tools and infrastructure supporting laboratory operations, including sample and project tracking, and data organization. Pipeline development and automation: Develop, maintain, and troubleshoot bioinformatics pipelines and automated workflows using Python, Linux, and high-performance computing (HPC) environments. Reduce manual intervention and improve processing reliability. Scientific collaboration: Evaluate emerging bioinformatics methods and sequencing applications along with academic and commercial collaborators. QUALIFICATIONS Required PhD in Bioinformatics, Computational Biology, Computer Science, Life Sciences, or a related field, and a minimum of 0-2 years related experience; may include post-doctoral experience. Alternatively, Masters with a minimum of 3-5 years of relevant experience or B.S. with a minimum of 5-7 years of related experience. Proficiency in Python programming, including data processing. Strong working knowledge of Linux, including command-line tools, shell scripting, and file system organization. Experience with high-performance computing (HPC) environments, including job schedulers, computational resource allocation, and pipeline execution. Familiarity with scientific development practices include testing, version tool, code review, workflow management frameworks (e.g. WDL, NextFlow), reproducible computational environments (containers), and code documentation. Experience with next-generation sequencing data analysis and bioinformatics pipelines. Strong analytical, troubleshooting, and organizational skills, with the ability to independently solve technical problems and manage multiple priorities. Excellent written and verbal communication skills, including the ability to document workflows and explain complex technical concepts to diverse audiences. Preferred Experience working in a sequencing facility, genomics core laboratory, or commercial sequencing service provider. Experience with laboratory operations, including sample tracking, metadata management, and project coordination. Experience analyzing PacBio HiFi or other long-read sequencing data. Experience with cloud-based data storage and analysis, particularly AWS. Experience with SQL and relational databases for managing and querying scientific data. Familiarity with AI agentic software development tools like Claude Code or Codex. Experience in a customer-facing role. Experience communicating scientific results in conference presentations or peer-reviewed publications. Candidates must have current authorization to work in the United States without the need for present or future sponsorship. Non-Field Based Employees are required to be onsite Monday-Thursday (Friday work from home). Depending on the role, some employees may be required to be 100% onsite. You may be required from time to time to visit and work at PacBio locations and for such times as the Company considers necessary for the proper performance of your duties. All listed tasks and responsibilities are deemed as essential functions to this position; however, business conditions may require reasonable accommodations for additional tasks and responsibilities. All qualified applicants will receive consideration for employment without regard to race, sex, color, religion, national origin, protected veteran status, or on the basis of disability, gender identity, and sexual orientation. #LI-Onsite Salary Range: $112,000.00 - $168,000.00 To all Staffing and Recruiting Agencies: Our Careers Site is only for individuals seeking a job at PacBio. Staffing and recruiting agencies and individuals being represented by an agency are not authorized to use this site or to submit profiles, applications or resumes, and any such submissions will be considered unsolicited. PacBio does not accept unsolicited resumes or applications from agencies. Please do not forward resumes to our jobs alias, PacBio employees or any other company location. PacBio is not responsible for any fees related to unsolicited resumes/applications. All qualified applicants will receive consideration for employment without regard to race, sex, color, religion, national origin, protected veteran status, or on the basis of disability, gender identity, and sexual orientation. If you are an individual with a disability and require a reasonable accommodation to complete any part of the application process, or are limited in the ability or unable to access or use this online application process and need an alternative method for applying, you may contact us at 650-521-8000, or [email protected] for assistance. Visit our following pages for more information on: FAQs Benefits Culture Equal Opportunity Employment Beware of Recruitment Fraud Please be aware of employment scams where people or entities misuse PacBio’s name, or the names of PacBio employees, to post fake job advertisements or make fake job offers. PacBio will never extend a job offer without a personal interview and will never charge any money for joining our company. All current job openings are displayed on the Careers page of our official website. If you see a job posting that is not on the PacBio official website, or have been approached with a job offer that you suspect may be fraudulent, we strongly recommend you do not respond and do not send money or provide any personal information. IT IS LIKELY A SCAM OR FAKE JOB AD IF: The job offer requires you to pay something (for example, to purchase equipment). You receive a job offer that you didn’t apply for, or without a personal interview or interaction. The interview seems to involve AI video or audio. You found a job on a job board or third-party channel, but the job doesn’t exist on the official PacBio careers page You suspect it is a scam. HOW TO PROTECT YOURSELF: Never give personal and confidential information. Never pay for anything as part of interviewing for, or accepting, an offer of employment. Ignore it if it seems like a scam. At PacBio, we’re all on a mission to enable the promise of genomics to better human health. It’s what fuels us every day. Our team is passionate about catalyzing scientists pursuing biological discoveries, and we’re looking for exceptional individuals like you to join us. If you’re interested at being at the intersection where health and technology come together, then consider joining our team. We look forward to meeting you. CORE VALUES: BE CURIOUS. Our future depends on it. DELIGHT OUR CUSTOMERS. We strive to get it right every time. TAKE ACTION. We move fast and take calculated risks. EXECUTION MATTERS. Our customers rely on us. WORK TOGETHER. We care deeply about each other. Please be aware of employment scams where people or entities misuse PacBio’s name, or the names of PacBio employees, to post fake job advertisements or make fake job offers. PacBio will never extend a job offer without a personal interview and will never charge any money for joining our company. All current job openings are displayed on the Careers page of our official website. If you see a job posting that is not on the PacBio official website, or have been approached with a job offer that you suspect may be fraudulent, we strongly recommend you do not respond and do not send money or provide any personal information. IT IS LIKELY A SCAM OR FAKE JOB AD IF: The job offer requires you to pay something (for example, to purchase equipment). You receive a job offer that you didn’t apply for, or without a personal interview or interaction. The interview seems to involve AI video or audio. You found a job on a job board or third-party channel, but the job doesn’t exist on the official PacBio careers page You suspect it is a scam. HOW TO PROTECT YOURSELF: Never give personal and confidential information. Never pay for anything as part of interviewing for, or accepting, an offer of employment. Ignore it if it seems like a scam.

Scientist II, Bioinformatics (Applications Lab).

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