Job Description General Summary: The Senior Project Manager, Commercial Transformation is responsible for leading the planning, coordination, and execution of VITAL ’30 initiative(s) that improve Vertex’s commercial capabilities, operating models and processes. This role will partner with initiative leads, and cross-functional team members from Commercial, DTE, Finance and HR, to design operating model solutions and deliver transformation programs that enable growth and organizational effectiveness. The successful candidate is a highly organized, collaborative, and outcomes-oriented project leader who can translate strategic priorities into clear plans, manage complex dependencies, identify risks early, and drive accountable execution in a dynamic environment. This is a high-visibility role at the center of Vertex’s commercial transformation agenda, offering direct partnership with senior leadership and the opportunity to shape how the commercial organization operates and grows. Key Duties and Responsibilities: Lead end-to-end delivery of commercial transformation initiatives, from VITAL ’30 mobilization through implementation, adoption, and post-launch measurement. Develop integrated project plans, including objectives, milestones, workstreams, timelines, dependencies, resource needs, and success measures. Manage vendor relationships, cultivate strong partnerships, and oversee cross-functional teams to ensure work is sequenced effectively and deliverables are completed on time, within scope. Maintain project governance, meeting cadences, escalation pathways, and presence at decision-making forums. Monitor progress against plans; proactively identify issues, risks, dependencies, and mitigation actions. Generate strategic insights; synthesize performance data, benchmarking, stakeholder inputs to surface clear, evidence-based recommendations for senior leadership Drive organizational change enablement: develop adoption strategies, stakeholder engagement plans, and change impact assessments to support successful transformation Knowledge and Skills: Strong knowledge of project management methodologies, including scope, schedule, risk, issue, budget, and stakeholder management. Strong analytical and proactive problem-solving capabilities; breaks down complex challenges into clear frameworks and actionable recommendations that drive informed decision-making. Strong written, verbal, facilitation, and executive communication skills. Adaptability with changing priorities, evolving requirements, and fast-moving business conditions; operates effectively without a fully defined roadmap Accountability for the deliverables within an initiative, follow-up on actions and facilitation of effective decision-making. Proficiency in Microsoft Office Suite, particularly PowerPoint for executive communications; familiarity with project management and collaboration tools such as Teams, SharePoint, and Smartsheet Education and Experience: Typically requires a bachelor's degree Typically requires 6 years of experience or the equivalent combination of education and experience At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients. Pay Range: $139,200 - $208,800 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time. #LI-Hybrid Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at [email protected] Help Us Achieve Our Mission Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases and conditions. The company has approved therapies for cystic fibrosis, sickle cell disease, transfusion-dependent beta thalassemia, acute pain and acromegaly, and it continues to advance clinical and research programs in these areas. Vertex also has a robust clinical pipeline of investigational therapies across a range of modalities in other serious diseases where it has deep insight into causal human biology, including IgA nephropathy, neuropathic pain, APOL1-mediated kidney disease, primary membranous nephropathy, congenital adrenal hyperplasia, ACTH-dependent Cushing's syndrome, autosomal dominant polycystic kidney disease, type 1 diabetes, generalized myasthenia gravis, and myotonic dystrophy type 1. Vertex was founded in 1989 and has its global headquarters in Boston, with international headquarters in London. Additionally, the company has research and development sites and commercial offices in North America, Europe, Australia, Latin America and the Middle East. Vertex is consistently recognized as one of the industry's top places to work, including 17 consecutive years on Science magazine's Top Employers list and one of Fortune’s 100 Best Companies to Work For. For company updates and to learn more about Vertex's history of innovation, visit www.vrtx.com or follow us on LinkedIn, Facebook, Instagram, YouTube, and X We believe our culture is one of Vertex’s greatest strengths and a key enabler of our ability to deliver transformative medicines for patients who need them. Rooted in innovation, purpose and collaboration, our culture empowers people to take smart risks, challenge conventional thinking and do their best work. The diversity of our people is central to that culture. By bringing together individuals with different backgrounds, experiences and perspectives, we foster an environment where new ideas thrive, better decisions are made and breakthrough innovation is possible. We are committed to creating a workplace where everyone feels valued, included and connected to our shared mission, because we know that our unique culture and the collective strength of our people are what set Vertex apart.

Senior Project Manager, Commercial Transformation.

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